Table 3 Prediction of clinicopathologically classified patients by the TILs-score

Age

≤ 50

92

(59.4%)

216

(53.9%)

3.182

(2.059–4.916)

< 0.0001

0.763

(0.712–0.810)

75.56 (70.0-80.6)

68.42

(51.3–82.5)

> 50

63

(30.6%)

185

(46.1%)

2.833

(1.806–4.442)

< 0.0001

0.739

(0.679–0.792)

80.09 (74.1–85.3)

56.76

(39.5–72.9)

Molecular subtype

Luminal A

66

(42.6%)

68

(17.0%)

2.736

(1.652–4.531)

< 0.0001

0.730

(0.647–0.803)

62.11

(51.6–71.9)

76.92

(60.7–88.9)

Luminal B

36

(23.2%)

142

(35.4%)

3.139

(1.720–5.729)

< 0.0001

0.745

(0.675–0.808)

83.44

(76.7–88.9)

52.38

(29.8–74.3)

HER2-enriched

30

(19.4%)

94

(23.4%)

1.316

(0.565–3.065)

0.525

0.558

(0.467–0.648)

76.52

(67.7–83.9)

33.33

(7.5–70.1)

Triple-negative

23

(14.8%)

97

(24.2%)

2.283

(0.859–6.066)

0.098

0.633

(0.540–0.719)

82.46

(74.2–88.9)

50.0

(11.8–88.2)

Tumor size

≤ 2 cm

86

(55.5%)

151

(37.7%)

2.372

(1.609–3.497)

< 0.0001

0.716

(0.654–0.773)

71.35

(64.4–77.6)

68.89

(53.4–81.8)

> 2 cm

69

(44.5%)

250

(62.3%)

3.729

(2.175–6.391)

< 0.0001

0.760

(0.710–0.806)

81.31

(76.3–85.6)

53.33

(34.3–71.7)

Nodes metastasis

0

89

(57.4%)

201

(50.1%)

2.922

(1.970–4.334)

< 0.0001

0.750

(0.696–0.798)

76.13

(70.3–81.3)

65.96

(50.7–79.1)

1–3

31

(20.0%)

101

(25.2%)

3.383

(1.685–6.792)

0.001

0.778

(0.698–0.846)

81.90

(73.7–88.4)

62.50

(35.4–84.8)

≥ 4

35

(22.6%)

99

(24.7%)

2.533

(1.190–5.392)

0.016

0.701

(0.616–0.777)

75.41

(66.8–82.8)

50.00

(21.1–78.9)

ER

Negative

50

(32.3%)

187

(46.6%)

1.693 (0.889–3.224)

0.109

0.598 (0.533–0.661)

79.73 (73.8–84.8)

40.00 (16.3–67.7)

Positive

105

(67.7%)

214

(53.4%)

3.229 (2.223–4.692)

< 0.0001

0.770 (0.720–0.815)

74.90 (69.2–80.1)

68.33 (55.0–79.7)

PR

Negative

63

(40.6%)

216

(53.9%)

1.939 (1.117–3.366)

0.019

0.636 (0.576–0.692)

79.07 (73.6–83.9)

42.86 (21.8–66.0)

Positive

92

(59.4%)

185

(46.1%)

3.260 (2.195–4.843)

< 0.0001

0.775 (0.721–0.823)

75.78 (69.6–81.3)

70.37 (56.4–82.0)

HER2

Negative

112

(72.3%)

261

(65.1%)

3.400 (2.338–4.945)

< 0.0001

0.778 (0.732–0.819)

76.97 (71.9–81.5)

69.64 (55.9–81.2)

Positive

43

(27.7%)

140

(34.9%)

2.010 (1.127–3.585)

0.018

0.660 (0.587–0.729)

78.66 (71.6–84.7)

42.11 (20.3–66.5)