Table 3 Univariable and multivariable Cox-regression analysis for recurrence-free survival (RFS) of patients in the derivation cohort
Variables | HR comparison | UV HR (95% CI) | UV P value | MV HR (95% CI) | MV P value |
|---|---|---|---|---|---|
Age | > 60 vs. ≤ 60 years | 1.18 (0.93–1.34) | 0.229 | ||
Gender | Male vs. Female | 0.93 (0.78–1.11) | 0.455 | ||
HBV (+) | HBV vs. non-HBV | 1.00 (0.85–1.19) | 0.924 | ||
ASA score | ≥ 2 vs. < 2 | 1.34 (1.11–1.61) | 0.002 | 1.36 (1.13–1.67) | 0.002 |
Cirrhosis | Yes vs. No | 1.31 (1.09–1.57) | 0.021 | NS | 0.087 |
Child-Pugh grade | B vs. A | 1.06 (0.72–1.55) | 0.757 | ||
Preoperative platelet counts | < 100 vs. ≥ 100 × 109/L | 0.73 (0.53 -1.00) | 0.051 | ||
Preoperative NLR | > 4 vs. ≤ 4 | 1.39 (1.14–1.70) | 0.001 | NS | 0.614 |
Preoperative CA 19 − 9 | > 37 vs. ≤ 37 U/mL | 1.55 (1.31–1.83) | < 0.001 | 1.25 (1.09–1.57) | 0.007 |
Tumor differentiation | Poor or moderate vs. Well | 1.02 (0.74–1.31) | 0.918 | ||
Type of resection | Major vs. Minor | 1.23 (1.03–1.45) | 0.016 | NS | 0.683 |
Macrovascular invasion | Yes vs. No | 1.37 (1.08–1.74) | 0.009 | NS | 0.096 |
Microvascular invasion | Yes vs. No | 1.35 (1.09–1.68) | 0.006 | NS | 0.172 |
Resection margin status | R1 vs. R0 | 1.31 (1.01–1.72) | 0.044 | NS | 0.412 |
Postoperative adjuvant therapy | Yes vs. No | 0.99 (0.83–1.18) | 0.927 | ||
AJCC staging system8th | III/IV vs. I/II | 2.34 (1.93–2.83) | < 0.001 | 1.72 (1.42–2.08) | < 0.001 |
CTC grade | Intermediate vs. Low | 1.79 (1.48–2.16) | < 0.001 | 1.66 (1.35–2.05) | < 0.001 |
High vs. Low | 2.75 (2.17–3.49) | < 0.001 | 2.55 (1.97–3.24) | < 0.001 |