Fig. 3

Tissues of glioblastoma patients express CD13 on RNA and protein level. (A) TCGA database was analyzed concerning CD13 gene expression of glioblastoma tissues. Relative gene expression of CD13 is depicted of each patient (Firehose Legacy, mRNA data, U133 microarray, n = 528). Dotted line: relative gene expression “1” (upregulated) and “-1” (downregulated). (B) Brain tissues of patients suffered from epilepsy (EP), astrocytoma grade III (A°III) and glioblastoma (GBM) were stained for CD13 (green) and nuclei (DAPI, blue). Scale bars, 100 μm. (C) Graph depicts area of CD13 expression within tissue of different brain pathologies (n = 4–8, each dot represents data of one image, three different tissue regions and 18–26 images/patient). *P < 0.05 (ANOVA and Bonferroni correction)