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Fig. 6 | BMC Cancer

Fig. 6

From: High expression of RTEL1 predicates worse progression in gliomas and promotes tumorigenesis through JNK/ELK1 cascade

Fig. 6

JNK inhibitor reverse the malignant biological of RTEL1 overexpression in glioma cells. (A) MTT assay was used to examine the proliferation effect of RTEL1 overexpression combination with AS602801 treatment in U87 and SF295 cells. JNK inhibitor AS602801 could significantly decreased cell proliferation ability up-regulated by RTEL1 overexpression both in U87 and SF295 cells. (B) The impact of RTEL1 overexpression combination with AS602801 treatment on colony formation ability of glioma cells U87 and SF295. JNK inhibitor AS602801 could significantly decreased cell migration and invasion ability up-regulated by RTEL1 overexpression both in U87 and SF295 cells. Vector represents empty plasmid pcDNA3.1(−); RTEL1 represents RTEL1 overexpression plasmid pcDNA3.1(−)-RTEL1; AS602801 represents JNK inhibitor (10 μM). Mann–Whitney U test was used and data were expressed as mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001

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BMC Cancer

ISSN: 1471-2407

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