Table 3 Genes analyzed in each drug and their primer sequences, as well as the primer sequence of beta-actin gene as a control gene (endogenous reference)

Bempedoic acid

Cdh1

Forward: 5´- GCTGTTTCTTCGGAGGAGAGCG-3´

Reverse: 5´- CATGAGGGTTGGTGCAACGTCG-3´

Twist-1

Forward: 5´-GGAGTCCGCAGTCTTACGAGG-3´

Reverse: 5´-GCTCTGGAGGACCTGGTAGAG-3´

Famciclovir

MMP1

Forward: 5´-GGGAAACCAGATGCTGAAACC-3´

Reverse: 5´- GGCTTTCTCAATGGCATGGTCC-3´

Tezacaftor

SFN

Forward: 5´- TCATTGACTCAGCCCGGTCAGC-3´

Reverse: 5´- TGTCAGGTTGTCTCGCAGCAGC-3´

SOX4

Forward: 5´- AACCAACAATGCCGAGAACACG-3´

Reverse: 5´- ATCTGCGACCACACCATGAAGG-3´

Fenticonazole

BAD

Forward: 5´- TCCTGGTGGGATCGGAACTTGG-3´

Reverse: 5´- TCACACGCACCGGAAGGGAATC-3´

STMN1

Forward: 5´- AACTGGAGAAGCGTGCCTCAGG-3´

Reverse: 5´- TCAGCTTCATGGGACTTGCGTC-3´

Endogenous reference

β-actin

Forward: 5′ -TCATGAAGTGTGACGTGGACATC 3′

Reverse: 5′ CAGGAGGAGCAATGATCTTGATCT 3′