No. | Authors and years | Country | piRNA type(s) | piRNA(s) quantification | No. of patients | No. of control | Analysis method | Hazard ratio (HR) (95%CI) | Median follow-up months | Ref. |
---|---|---|---|---|---|---|---|---|---|---|
1 | Huiying Han, et al. (2021) | China | piRNA-30473 | Microarray analysis | 42 | N/A | Univariate and multivariate | Univariate analysis: HR = 2.193836 | 50 | [41] |
Multivariate analysis: HR = 1.9892 | ||||||||||
2 | Guoqing Li, et al (2023) | China | piRNA-25783 | ISH | 15 | N/A | Not reported | HR = 1.006 | 72 | [42] |
3 | Lisha Ai et al (2019) | China | piRNA-823 | qRT-PCR | 72 | N/A | Not reported | HR = 2.50 | 40 | [43] |
4 | Robert Iliev, et al (2016) | Czech Republic | piRNA-823 | qRT-PCR | 472 | 116 | Not reported | HR = 1.024 | 150 | [26] |
5 | Jonas Busch, et al (2015) | Germany | piRNA-30924, piRNA-57125, and piRNA-38756 | Microarray analysis | 106 | 77 | Univariate and multivariate | Univariate analysis: piRNA-30924 HR = 2.90, piRNA-57125 HR = 0.30, and piRNA-38756 HR = 3.96 | 120 | [44] |
Multivariate analysis: piRNA-30924 HR = 2.04, piRNA-57125 HR = 0.50, and piRNA-38756 HR = 1.93 | ||||||||||
6 | Ailin Qu, et al (2019) | China | piRNA-001311, piRNA-004153, piRNA-017723, piRNA-017724, and piRNA-019752 | Illumina high-throughput sequencing (HTS) | 220 | 220 | Univariate and multivariate | Univariate analysis: piRNA-001311 HR = 0.626, piRNA-004153, HR = 1.048, piRNA-017723, HR = 0.769, piRNA-017724, HR = 0.231, and piRNA-019752, HR = 0.611 | 60 | [13] |
Multivariate analysis: piRNA-017724, HR = 0.250 | ||||||||||
7 | Michael Bartos, et al (2021) | Czechia | piRNA-1849, piRNA-9491, piRNA-12487, piRNA-12488, and piRNA-23231 | RNA sequencing | 96 | 34 | Not reported | HR for piRNA-23231 = -0.497 | 60 | [45] |
8 | Xiaorong Zhou, et al (2020) | China | piRNA-1245 | qRT-PCR | 66 | 66 | Univariate and multivariate | Univariate analysis: HR = 2.183 | 60 | [46] |
Multivariate analysis: HR = 2.989 | ||||||||||
9 | Victor D Martinez, et al (2016) | Canada | FR222326 | RNA sequencing | 320 | 38 | Not reported | HR = 10.22 | 100 | [47] |
10 | Aswini R. Krishnan, et al (2016) | USA | NONHSAT123636, NONHSAT113708, NONHSAT067200, and NONHSAT081250 | RNA sequencing | 256 | N/A | Not reported | HR for NONHSAT067200 = 1.897 | 134 | [48] |
11 | Maarouf A Saad, et al (2019) | USA | piRNA-35373, piRNA-266308, piRNA-58510, and piRNA-38034, | RNA sequencing | 40 | N/A | Univariate and multivariate | Univariate analysis: piRNA-58510 HR = 0.072, and piRNA-35373 HR = 0.17 | 134 | [49] |
Multivariate analysis: piR-58510 HR = 0.063, and piR-3537 HR = 0.089 | ||||||||||
12 | Chenming Zhao, et al (2019) | Germany | piRNA-34536, and piR-51810 | qRT-PCR | 148 | 90 | Univariate and multivariate | Univariate analysis: piRNA-34536 HR = 0.295, and piRNA-51810 HR = 0.205 | 150 | [50] |
Multivariate analysis: piRNA-34536 HR = 0.275, and piRNA-51810 HR = 0.223 | ||||||||||
13 | Dan Li, et.al (2016) | China | piRNA-651 | qRT-PCR | 78 | N/A | Not reported | HR = 0.002 | 25 | [25] |
14 | Preethi Krishnan, et al (2016) | Canada | piRNA-009051, and piRNA-021032a | RNA sequencing | 104 | 11 | Univariate and multivariate | Univariate analysis: HR = 2.31 | 200 | [51] |
Multivariate analysis: HR = 2.29 | ||||||||||
15 | Anna Cordeiro, et al (2016) | Spain | piRNA-651 | qRT-PCR | 94 | N/A | Not reported | HR = -1.297a | 250 | [52] |
16 | Wenhao Weng et al (2018) | USA | piRNA-1245 | RNA sequencing | 189 | 195 | Univariate and multivariate | Univariate HR = 3.208 | 133 | [53] |
Multivariate HR = 2.9347 | ||||||||||
17 | Junlan Feng et al (2020) | China | piRNA-823 | Microarray analysis | 176 | N/A | Univariate and multivariate | Univariate HR = 7.49 | 150 | [27] |
Multivariate HR = 8.02 | ||||||||||
18 | Dongmei Mai et al (2018) | China | piRNA-54265 | qRT-PCR | 535 | N/A | Univariate and multivariate | Univariate HR = 2.02 | 70 | [24] |
Multivariate HR = 1.99 | ||||||||||
19 | Natalie Firmino et al (2016) | Canada | FR018916, FR140858, FR197104, FR237180, and FR298757 | RNA sequencing | 455 | 43 | not reported | FR018916, HR = 0.882, FR140858 HR = 1.000b, FR197104 HR = 0.091, FR237180 HR = 1.003, and FR298757 HR = 1.009 | 100 | [54] |
20 | Wentao Zhang et al (2023) | China | piRNA-1742 | RNA sequencing | 96 | N/A | not reported | Univariate analysis: piR-1742 HR = 2.232 | 120 | [55] |
Multivariate analysis: piR-1742 HR = 1.993 |