Authors | Cancer type | Sample type | Exploring the Influence of piRNA on biological outcomes |
---|---|---|---|
Huiying Han, et al | DLBCL | FFPE | Patients with a poor prognosis exhibited a significant increase in piRNA-30473 expression level in comparison to those with a favorable prognosis |
Guoqing Li et al | OC | FFPE | High expression of piRNA-25783 in tumors is associated with shorter overall survival of patients compared to those with low expression |
Lisha Ai, et al | MM | BM aspirates and PB | High expression of piRNA-piRNA-823 is correlated with reduced overall survival |
Robert Iliev, et al | RCC | Tissue, Serum and Urine | High expression of piRNA-823 in tumor tissue is associated with unfavorable clinical outcomes |
Jonas Busch, et al | RCC | Fresh-frozen tissues | The study found that increased levels of piRNA-30924 and piRNA-38756, and decreased levels of piRNA-57125 in metastatic primary tumors were strongly linked to tumor recurrence and shorter overall survival |
Ailin Qu, et al | CRC | Serum | Low piRNA-017724 expression leads to lower OS and PFS rates compared to high expression |
Michael Bartos, et al | GBM | Fresh-frozen tissues | Only piRNA-23231 was significantly decreased in GBM, which may play a role in GBM behavior and poorer survival. Additionally, piRNA-23231 shows promise as a potential prognostic biomarker |
Xiaorong Zhou, et al | GC | GJ | High piRNA-1245 expression in gastric juice is associated with poorer OS and PFS in patients with gastric cancer |
Victor D Martinez, et al | GC | Tissue | Only FR222326 was significantly associated with overall survival. Notably, lower expression levels of FR222326 were strongly correlated with a poorer prognosis in patients |
Aswini R. Krishnan, et al | HNSCC | Tissue | The study found that NONHSAT067200, a piRNA that is downregulated in smoking-induced HNSCCs, was significantly associated with poor survival in patients |
Maarouf A Saad, et al | HNSCC | Tissue | Low expression of piRNA-58510 and piRNA-35373 were found to significantly correlate with improved patient survival |
Chenming Zhao, et al | RCC | Tissue and serum | piRNA-34536 and piRNA-51810 were found to be downregulated in ccRCC. Decreased tissue piRNA levels were found to be significant and independent predictors of shortened PFS, CSS, and OS in ccRCC patients |
Dan Li, et al | NSCLC | Tissue | The study suggests that piRNA-651 functions as an oncogene in NSCLC, and that high expression levels of piRNA-651 are associated with a higher risk of death among patients with NSCLC |
Preethi Krishnan, et al | BC | FFPE | The study found that hsa_piRNA_021032 was upregulated in tumor tissues and appeared to contribute to lower overall survival |
Anna Cordeiro, et al | HL | FFPE | Patients who had low levels of piR-651 experienced a poorer outcome |
Wenhao Weng et al | CRC | Tissue | Patients with high expression levels of piRNA-1245 demonstrated a significant inclination towards unfavorable overall survival outcomes |
Junlan Feng et al | CRC | Tissue | Patients with CRC who overexpress piRNA-823 are more likely to experience unfavorable overall survival and exhibit a diminished response to adjuvant chemotherapy |
Dongmei Mai et al | CRC | Tissue and serum | Levels of piRNA-54265 in CRC tissues were strongly correlated with the levels in the serum of patients. Furthermore, both tissue and serum levels of piRNA-54265 were found to be highly associated with clinical outcomes, including resistance to chemotherapy and poor survival in CRC patients |
Natalie Firmino et al | HNSCC | Tissue | A group of patients with HPV-positive HNSCC who have a poor prognosis can be identified using a five-piRNA signature, which underscores the potential usefulness of piRNAs in managing patients |
Wentao Zhang et al | RCC | Tissue | There is a significant association between high levels of piRNA-1742 expression in RCC samples and unfavorable clinical outcomes |