Fig. 4

The comprehensive metabolic analysis of metabolomic difference of PC vs. PDXG1 and PDXG1 vs. PDXG3. Figure 4A. The scores plot of principal component analysis (PCA) of ¹H NMR spectral data derived from PC, PDXG1 and PDXG3. Figure 4B. The heatmap of correlation coefficient between critical metabolites involved in glycolysis/TCA metabolism in comparisons of PC vs. PDXG1 and PDXG1 vs. PDXG3. The cool-toned color of boxes represents a negative correlation while the warm-toned color represents a positive correlation. Figure 4C. The metabolic flux of TCA-associated metabolisms in the metabolomic comparisons between PC, PDXG1 and PDXG3. Each box represents a metabolite. The three solid boxes under metabolites represent the p value of t tests of metabolites in comparisons of PC vs. PDXG1, PC vs. PDXG3 and PDXG1 vs. PDXG3, respectively. The cool-toned color of boxes represents that the corresponding metabolite in latter group was significantly lower than the former group, while the warm-toned color represents a relatively high level of metabolites in latter group. KEGG was used as important reference for figure drawing [18,19,20]