From: Expression of STAT3 and hypoxia markers in long-term surviving malignant glioma patients
IHC analysis of hypoxia related markers | |||||||||||||||||||
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sample | resection | MGMT prom. methylation | EGFR amplified yes/no | ATRX - L = loss; P = positivity | p53 | Olig2% | SOX10% | SOX11% | MEOX2% | CD44% | MERTK % | Vimentin % | ZEB1% | ZEB2% | TWIST % | HIF1a % | HIF1b % | STAT3% | pSTAT3% |
Le | 1st | no | no | L | mut | 65 | 0 | 0 | 35 | 100 | 10 | 35 | 95 | 10 | 70 | 1 | 0 | 0 | 20 |
 | 2nd | no | no | P | mut | = | - | - | - | = | - | ↑ | - | ↑ | ↓ | - | ↑ | - | ↑ |
 | 3rd | no | no | P | mut | ↓ | = | ↑ | ↓ | = | ↓ | ↓ | ↓ | ↓ | = | ↑ | ↓ | ↑ | ↑ |
 | 4th | no | no | P | mut | ↑ | = | ↑ | ↑ | = | ↑ | ↑ | ↑ | ↑ | ↑ | ↓ | ↑ | ↑ | ↑ |
Pu | 1st | no | no | P | mut | 95 | 0 | 10 | 95 | 95 | - | 100 | - | 100 | 100 | 0 | 60 | 100 | 40 |
 | 2nd | no | no | L | mut | ↓ | ↑ | ↓ | ↓ | ↑ | - | ↓ | 75 | = | ↓ | = | ↓ | - | ↑ |
 | 3rd | no | no | P | mut | ↑ | ↓ | ↑ | ↑ | ↑ | 27 | ↑ | ↑ | = | ↑ | = | ↑ | = | ↑ |
Ku | 1st | no | no | P | wt | 100 | 85 | 80 | 0 | 95 | 10 | 12 | 95 | 100 | 40 | 0 | 80 | 60 | 35 |
 | 2nd | no | no | P | wt | ↓ | ↑ | ↓ | = | ↑ | - | ↓ | ↓ | - | - | = | = | - | ↑ |
Do | 1st | yes | yes | L | wt | 85 | 0 | 3 | 5 | 87 | 5 | 100 | 100 | 100 | 100 | 0 | 0 | - | 5 |
 | 2nd | yes | yes | P | wt | ↓ | = | ↓ | ↑ | ↑ | - | ↓ | = | - | = | = | ↑ | 70 | ↑ |
Jo | 1st | yes | yes | L | wt | 40 | 0 | 0 | 15 | 100 | 5 | 95 | 35 | 100 | 0 | 0 | 15 | - | 85 |
 | 2nd | yes | yes | P | wt | ↓ | = | ↑ | ↓ | = | ↑ | ↑ | ↑ | = | ↑ | ↑ | - | 50 | ↑ |
Du | 1st | no | yes | P | wt | 32 | 0 | 15 | 25 | 100 | - | 100 | - | 100 | 5 | 0 | 35 | 60 | 35 |
 | 2nd | no | yes | L | wt | ↓ | ↑ | ↓ | ↓ | = | 5 | ↓ | 60 | ↓ | = | = | ↓ | 60 | ↑ |
Bi | 1st | yes | no | P | mut | 50 | 40 | 20 | 10 | 100 | 20 | 82 | 65 | 100 | 50 | 0 | 20 | 90 | 85 |
 | 2nd | yes | no | P | mut | ↓ | ↓ | ↓ | ↓ | = | ↓ | ↓ | ↓ | = | ↓ | ↑ | = | ↓ | ↓ |
Ná | 1st | no | no | L | wt | 60 | 50 | 5 | 0 | 100 | 20 | 80 | 95 | 100 | 90 | 0 | 40 | 95 | 70 |
 | 2nd | no | no | L | wt | ↓ | ↓ | ↓ | = | = | ↓ | ↓ | ↓ | ↓ | ↓ | = | ↓ | ↓ | ↑ |