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Table 1 Criteria for clinical complete response

From: The efficacy and safety of short-course radiotherapy followed by sequential chemotherapy and Cadonilimab for locally advanced rectal cancer: a protocol of a phase II study

Diagnosis criteria

1. Substantial downsizing with no residual tumor or residual fibrosis only (with low signal on high b-value DWI, if available)

2. No suspicious lymph nodes on MRI

3. No residual tumor at endoscopy or only a small residual erythematous ulcer or scar

4. Negative biopsies from the scar, ulcer, or former tumor location

5. No palpable tumor, when initially palpable with digital rectal examination

  1. Abbreviation: DWI Diffusion weighted imaging, MRI Magnetic resonance imaging
  2. If patients did not meet all of these criteria, the diagnosis of clinical complete response could not be validated