Table 1 Clinicopathological parameters of 124 NPC patients with regional failure
Parameters | Subgroup | Surgery group | Re-irradiation group | P |
|---|---|---|---|---|
NO. (%) | NO. (%) | |||
Age at recurrence (y) | < 50 | 32 (58.2) | 36 (52.2) | 0.587 |
≥ 50 | 23 (41.8) | 33 (47.8) | ||
Gender | Male | 45 (81.8) | 48 (69.6) | 0.146 |
Female | 10 (18.2) | 21 (30.4) | ||
Initial T classification | T1 | 12 (23.5) | 8 (12.3) | 0.433 |
T2 | 20 (39.2) | 26 (40.0) | ||
T3 | 14 (27.5) | 22 (33.8) | ||
T4 | 5 (9.8) | 9 (13.8) | ||
Initial N classification | N1 | 9 (18.0) | 13 (20.3) | 0.603 |
N2 | 23 (46.0) | 23 (35.9) | ||
N3 | 18 (36.0) | 28 (43.8) | ||
Initial Clinical stage | I | 1 (2.0) | 0 (0) | 0.661 |
II | 4 (8.0) | 5 (7.7) | ||
III | 23 (46.0) | 26 (40.0) | ||
IV | 22 (44.0) | 34 (53.3) | ||
rN classification | rN1 | 41 (75.4) | 53 (76.8) | 0.003 |
rN2 | 4 (7.3) | 14 (20.3) | ||
rN3 | 10 (18.2) | 2 (2.9) | ||
Chemotherapy before recurrent | No | 6 (11.3) | 5(7.5) | 0.534 |
Yes | 47 (88.7) | 62 (92.5) | ||
rENE | Without | 28 (51.9) | 31 (45.6) | 0.467 |
With | 26 (48.1) | 37 (54.4) | ||
Failure patterns | In-field | 46 (83.6) | 50 (72.5) | 0.194 |
Out-field | 9 (16.4) | 19 (27.5) | ||
Chemotherapy at recurrent | No | 35 (63.6) | 8 (11.6) | < 0.001 |
Yes | 20 (36.4) | 61 (88.4) | ||
Pretreatment EBV-DNA | < 589 | 17 (50.0) | 31 (58.5) | 0.510 |
≥ 589 | 17 (50.0) | 22 (41.5) |