Table 2 Univariate analysis of potential prognostic factors
Characteristics | Subgroups | OS | RRFS | DMFS | |||
|---|---|---|---|---|---|---|---|
5-year (%) | P | 5-year (%) | P | 5-year (%) | P | ||
Gender | Male | 72.5 | 0.380 | 67.1 | 0.810 | 74.1 | 0.231 |
Female | 78.3 | 68.2 | 82.7 | ||||
Age at recurrence (y) | < 50 | 83.4 | 0.013 | 70.3 | 0.497 | 74.2 | 0.677 |
≥ 50 | 62.9 | 63.6 | 78.7 | ||||
Treatment after recurrent | Surgery | 75.6 | 0.973 | 62.7 | 0.330 | 77.4 | 0.901 |
Re-irradiation | 72.4 | 71.1 | 74.9 | ||||
Chemotherapy before recurrent | No | 78.8 | 0.830 | 63.6 | 0.389 | 79.5 | 0.720 |
Yes | 73.5 | 68.0 | 74.5 | ||||
rN classification | rN1-2 | 77.1 | 0.015 | 66.4 | 0.301 | 76.3 | 0.668 |
rN3 | 48.9 | 76.2 | 74.1 | ||||
rENE | Without | 87.3 | 0.007 | 75.9 | 0.364 | 92.9 | 0.001 |
With | 63.1 | 60.9 | 60.8 | ||||
MAD of recurrent lymph nodes | < 3 cm | 74.9 | 0.487 | 72.5 | 0.214 | 74.7 | 0.861 |
≥ 3 cm | 73.0 | 61.9 | 803 | ||||
Failure patterns | In-field | 74.1 | 0.732 | 70.9 | 0.168 | 81.0 | 0.019 |
Out-field | 72.9 | 56.2 | 60.9 | ||||
Bilateral of LN | No | 73.9 | 0.515 | 68.0 | 0.618 | 75.7 | 0.632 |
Yes | 74.7 | 64.2 | 78.9 | ||||
Chemotherapy after recurrent | No | 73.2 | 0.725 | 63.6 | 0.960 | 75.6 | 0.747 |
Yes | 73.7 | 68.6 | 75.1 | ||||
Pretreatment EBV-DNA | < 589 | 82.1 | 0.158 | 65.0 | 0.045 | 76.9 | 0.795 |
≥ 589 | 70.9 | 89.1 | 84.2 | ||||