Efficacy of salvage surgery versus re-irradiation for isolated regional lymph node recurrence in patients with nasopharyngeal carcinoma

Table 3 Multivariate analysis of potential prognostic factors

	Factors	HR (95%CI)	P
OS	Age at recurrence (< 50 vs. ≥ 50 years)	2.23 (1.08–4.59)	0.030
	rENE (without vs. with)	2.64 (1.21–5.74)	0.014
	rN classification (rN1–2 vs. rN3)	2.42 (1.02–5.76)	0.045
RRFS	Pretreatment EBV-DNA (< 589 vs ≥ 589)	0.341 (0.11–1.03)	0.056
DMFS	rENE (without vs. with)	4.87 (1.65–14.40)	0.004
DMFS	Failure patterns (in-field vs. out-field)	2.20 (0.97–4.99)	0.060

Abbreviation: HR hazard ratio, CI confidence interval, OS overall survival, RRFS regionl recurrence-free survival, DMFS distant metastasis-free survival, rENE radiology extra-nodal extension

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