Table 1 Characteristics of included studies
Author | Year | Country | Sample size | Over- expression | Detection method | Evaluation standard of TRIM overexpression | End-points (analysis type) | Follow-up | NOS score |
|---|---|---|---|---|---|---|---|---|---|
Seán Fitzgerald | 2013 | Ireland | 137 | 42 | IHC | staining intensity > 2 units of difference | OS, RFS | median follow up of 54 months (range 1–122 months) | 6 |
Hong XW | 2016 | China | 90 | 45 | qPCR | median value of mRNA levels | OS | NR | 8 |
Wang FQ | 2017 | China | 97 | 61 | IHC | percentage of positive cells > 25% | OS | NR | 8 |
Ma SZ | 2017 | China | 145 | 97 | IHC | percentage of positive cells > 50% | OS | ≥ 60 months | 8 |
Zhang Y | 2018 | China | 50 | 42 | IHC | Final staining score > 4 | OS | Median follow up of 60months | 8 |
Wang HY | 2018 | China | 87 | 44 | IHC | Final staining score > 5 | OS | NR | 8 |
Chen DC | 2018 | China | 374 | 314 | IHC | Final staining score > 4 | OS | NR | 7 |
Li CG | 2019 | China | 120 | 65 | IHC | Final staining score > 1 | OS | mean follow-up of 43.6± 38.4 months (range, 4–132 months). | 8 |
Liang Q | 2019 | China | 180 | 90 | IHC | Final staining score > 6 | OS | NR | 8 |
Ding Y | 2020 | China | 129 | 75 | IHC | Final staining score > 6 | OS, RFS | ≥ 40 months | 8 |
Han YD | 2020 | China | 119 | 69 | IHC | Final staining score > 3 | OS | NR | 8 |
Zhang SE | 2020 | China | 90 | 56 | IHC | percentage of positive cells > 25% | OS | NR | 8 |