Table 2 Immunohistochemical expression of DOK3 and M2-TAMs in 139 OSCC patients with strong P. gingivalis staining according to the clinical data and follow-up

Sex

0.406

0.085^*

 Male

27 (57.4)

46 (50.0)

27 (44.3)

46 (59.0)

 Female

20 (42.6)

46 (50.0)

34 (55.7)

32 (41.0)

Age (yr)

0.042^*

0.372

 < 60

22 (46.8)

27 (29.3)

24 (39.3)

25 (32.1)

 ≥ 60

25 (53.2)

65 (70.7)

37 (60.7)

53 (67.9)

Survival status

0.004^**

0.052

 Alive

36 (76.6)

47 (51.1)

42 (68.9)

41 (52.6)

 Dead

11 (23.4)

45 (48.9)

19 (31.1)

37 (47.4)

Tobacco smoking

0.026^*

0.632

 No

18 (38.3)

19 (20.7)

15 (24.6)

22 (28.2)

 Yes

29 (61.7)

73 (79.3)

46 (75.4)

56 (71.8)

Alcohol consumption

0.614

0.000^***

 No

21 (44.7)

37 (40.2)

35 (57.4)

23 (29.5)

 Yes

26 (55.3)

55 (59.8)

26 (42.6)

55 (70.5)

Baseline severe dysphagia (Gr.3–6)

0.000^***

0.028^*

 No

38 (80.9)

41 (44.6)

43 (70.5)

36 (46.2)

 Yes

9 (19.1)

51 (55.4)

18 (29.5)

42 (53.8)

Diet

0.138

0.097

 Vegetarian

7 (14.9)

0

5 (8.2)

2 (2.6)

 Non-vegetarian

40 (85.1)

92 (100)

56 (91.8)

76 (97.4)

Milk & dairy products

0.677

0.240

 Never

1 (2.1)

1 (1.1)

0

2 (2.6)

 Less than once a week

10 (21.3)

12 (13.0)

10 (16.4)

12 (15.4)

 More than once a week

36 (76.6)

79 (85.9)

51 (83.6)

64 (82.0)

T stage

0.023^*

0.017^*

 T1 ~ T2

31 (66.0)

42 (45.7)

39 (63.9)

34 (43.6)

 T3 ~ T4

16 (34.0)

50 (54.3)

22 (36.1)

44 (56.4)

N stage

0.088

0.319

 N0

34 (72.3)

53 (57.6)

41 (67.2)

46 (59.0)

 N ( +)

13 (27.7)

39 (42.4)

20 (32.8)

32 (41.0)

Clinical stage

0.697

0.025^*

 I ~ II

20 (42.6)

36 (39.1)

31 (50.8)

25 (32.1)

 III ~ IV

27 (57.4)

56 (60.9)

30 (49.2)

53 (67.9)

Recurrence

0.675

0.114

 Yes

9 (19.1)

15 (16.3)

7 (11.5)

17 (21.8)

 No

38 (80.9)

77 (83.7)

54 (88.5)

61 (78.2)

Tumor size (cm)

0.000^***

0.619

 < 3

29 (61.7)

27 (29.3)

26 (42.6)

30 (38.5)

 ≥ 3

18 (38.3)

65 (70.7)

35 (57.4)

48 (61.5)

Differentiation

0.256

0.083

 Well

33 (70.2)

47 (51.1)

42 (68.85)

38 (48.7)

 Moderate

10 (21.3)

28 (30.4)

14 (22.95)

24 (30.8)

 Poor

4 (8.5)

17 (18.5)

5 (8.20)

16 (20.5)

Oral hygiene habits

0.020^*

0.044^*

 Good

5 (10.6)

15 (16.3)

8 (13.1)

12 (15.4)

 Average

15 (31.9)

36 (39.1)

22 (36.1)

29 (37.2)

 Bad

27 (57.5)

41 (44.6)

31 (50.8)

37 (47.4)

Periodontal condition

0.013^*

0.248

 Well

15 (31.9)

13 (14.1)

15 (24.6)

13 (16.7)

 Poor

32 (68.1)

79 (85.9)

46 (75.4)

65 (83.3)

Treatment

0.175

0.035^*

 Surgery

11 (23.4)

36 (39.1)

19 (31.1)

28 (35.9)

 Radiotherapy

14 (29.8)

23 (25.0)

11 (18.0)

26 (33.3)

 Chemoradiation/comprehensive

22 (46.8)

33 (35.9)

31 (50.8)

24 (30.8)