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  1. Although the efficacy of tamoxifen (TAM) for breast cancer has been attributed to inducing cell cycle arrest and apoptosis by inhibiting estrogen receptor (ER) signaling, recent evidence indicates that TAM als...

    Authors: Qian Wang, Yu Cheng, Yan Wang, Yibo Fan, Ce Li, Ye Zhang, Yiding Wang, Qian Dong, Yanju Ma, Yue-e Teng, Xiujuan Qu and Yunpeng Liu
    Citation: BMC Cancer 2017 17:492
    Content type: Research article Published on:

  2. The ‘common variant, common disease’ model predicts that a significant component of hereditary breast cancer unexplained by pathogenic variants in moderate or high-penetrance genes is due to the cumulative eff...

    Authors: Tatiane Yanes, Bettina Meiser, Mary-Anne Young, Rajneesh Kaur, Gillian Mitchell, Kristine Barlow-Stewart, Tony Roscioli, Jane Halliday and Paul James
    Citation: BMC Cancer 2017 17:491
    Content type: Study protocol Published on:

  3. Cytotoxic efficacy of anticancer drugs has been widely studied with monolayer-cultured cancer cells. However, the efficacy of drugs under two-dimensional (2D) culture condition usually differs from that of thr...

    Authors: Eva Lhuissier, Céline Bazille, Juliette Aury-Landas, Nicolas Girard, Julien Pontin, Martine Boittin, Karim Boumediene and Catherine Baugé
    Citation: BMC Cancer 2017 17:490
    Content type: Research article Published on:

  4. Epigenetic changes, including DNA methylation, disrupt normal cell function, thus contributing to multiple steps of carcinogenesis. Nasopharyngeal carcinoma (NPC) is endemic in southern China and is highly ass...

    Authors: Weilin Zhao, Yingxi Mo, Shumin Wang, Kaoru Midorikawa, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Guangwu Huang, Zhe Zhang, Mariko Murata and Kazuhiko Takeuchi
    Citation: BMC Cancer 2017 17:489
    Content type: Research article Published on:

  5. Aberrant Sonic Hedgehog/Gli (Hh/Gli) signaling pathway is a critical regulator of Sonic hedgehog medulloblastoma (SHH-MB). Cancer stem cells (CSCs), thought to be largely responsible for tumor initiation, main...

    Authors: Evelina Miele, Agnese Po, Federica Begalli, Laura Antonucci, Angela Mastronuzzi, Carlo Efisio Marras, Andrea Carai, Danilo Cucchi, Luana Abballe, Zein Mersini Besharat, Giuseppina Catanzaro, Paola Infante, Lucia Di Marcotullio, Gianluca Canettieri, Enrico De Smaele, Isabella Screpanti…
    Citation: BMC Cancer 2017 17:488
    Content type: Research article Published on:

  6. The disco-interacting protein 2 homolog C (DIP2C) gene is an uncharacterized gene found mutated in a subset of breast and lung cancers. To understand the role of DIP2C in tumour development we studied the gene in...

    Authors: Chatarina Larsson, Muhammad Akhtar Ali, Tatjana Pandzic, Anders M. Lindroth, Liqun He and Tobias Sjöblom
    Citation: BMC Cancer 2017 17:487
    Content type: Research article Published on:

  7. Mounting evidence has showed that Tumor-associated calcium signal transducer 2 (Trop2) is upregulated in various kinds of human cancers and plays important roles in tumorigenesis. However, the expression statu...

    Authors: Hongyu Guan, Zejun Guo, Weiwei Liang, Hai Li, Guohong Wei, Lijuan Xu, Haipeng Xiao and Yanbing Li
    Citation: BMC Cancer 2017 17:486
    Content type: Research article Published on:

  8. The serine/threonine protein kinases ROCK1 and 2 are key RhoA-mediated regulators of cell shape and cytoskeletal dynamics. These proteins perform multiple functions in vascular endothelial cell physiology and ...

    Authors: Clarissa N. Amaya, Dianne C. Mitchell and Brad A. Bryan
    Citation: BMC Cancer 2017 17:485
    Content type: Research article Published on:

  9. Serum carcinoembryonic antigen (CEA) levels are a predictor of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) efficacy and are associated with epidermal growth factor receptor (EGFR) gen...

    Authors: Yuan Gao, PingPing Song, Hui Li, Hui Jia and BaiJiang Zhang
    Citation: BMC Cancer 2017 17:484
    Content type: Research article Published on:

  10. The management of elderly patients with cancer is a therapeutic challenge and a public health problem. Definitive chemoradiotherapy (CRT) is an accepted standard treatment for patients with locally advanced es...

    Authors: Stéphanie Servagi-Vernat, Gilles Créhange, Franck Bonnetain, Cécile Mertens, Etienne Brain and Jean François Bosset
    Citation: BMC Cancer 2017 17:483
    Content type: Study protocol Published on:

  11. Both incidence and survival rates of hematological cancers are increasing, leading to a growing number of survivors with specific late and long-term effects. However, relevant research in physical, psychologic...

    Authors: Peter Esser, Katharina Kuba, Heide Götze and Anja Mehnert
    Citation: BMC Cancer 2017 17:482
    Content type: Study protocol Published on:

  12. This study aimed to evaluate the perioperative outcomes and prognostic impact of the consecutive steps of imaging, frailty assessment, and diagnostic laparoscopy (DLS) in patients with advanced epithelial ovar...

    Authors: Kyung Jin Eoh, Jung Won Yoon, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim and Young Tae Kim
    Citation: BMC Cancer 2017 17:481
    Content type: Research article Published on:

  13. While many factors may contribute to the higher prostate cancer incidence and mortality experienced by African-American men compared to their counterparts, the contribution of tumor biology is underexplored du...

    Authors: Jennifer S. Myers, Karin A. Vallega, Jason White, Kaixian Yu, Clayton C. Yates and Qing-Xiang Amy Sang
    Citation: BMC Cancer 2017 17:480
    Content type: Research article Published on:

  14. The study was aimed to quantitatively detect mRNA levels of the catalytic subunit of telomerase (hTERT) in both peripheral blood and circulating tumor cells (CTCs) of patients with nasopharyngeal carcinoma (NP...

    Authors: Xinsa Fu, Congxiang Shen, Huigang Wang, Fang Chen, Guanxue Li and Zhong Wen
    Citation: BMC Cancer 2017 17:479
    Content type: Research article Published on:

  15. Latinos born in the US, 36 million, comprise 65% of all US Latinos. Yet their cancer experience is nearly always analyzed together with their foreign-born counterparts, 19 million, who constitute a steady infl...

    Authors: Paulo S. Pinheiro, Karen E. Callahan, Scarlett Lin Gomez, Rafael Marcos-Gragera, Taylor R. Cobb, Aina Roca-Barcelo and Amelie G. Ramirez
    Citation: BMC Cancer 2017 17:478
    Content type: Research article Published on:

  16. Jumonji C domain 2A (JMJD2A), as a histone demethylases, plays a vital role in tumorigenesis and progression. But, its functions and underlying mechanisms of JMJD2A in nasopharyngeal carcinoma (NPC) metabolism...

    Authors: Yi Su, Qiu-hong Yu, Xiang-yun Wang, Li-ping Yu, Zong-feng Wang, Ying-chun Cao and Jian-dong Li
    Citation: BMC Cancer 2017 17:477
    Content type: Research article Published on:

  17. Although previous studies have reported the efficacy of communication skills training (CST) programs, specific training addressing communication about uncertainty and hope in oncology has not yet been studied....

    Authors: Yves Libert, Livia Peternelj, Isabelle Bragard, Aurore Liénard, Isabelle Merckaert, Christine Reynaert and Darius Razavi
    Citation: BMC Cancer 2017 17:476
    Content type: Study protocol Published on:

  18. Radical radiotherapy, with or without concomitant chemotherapy forms the mainstay of organ preservation approaches in mucosal primary head and neck cancer. Despite technical advances in cancer imaging and radi...

    Authors: Christopher N Rumley, Mark T Lee, Lois Holloway, Robba Rai, Myo Min, Dion Forstner, Allan Fowler and Gary Liney
    Citation: BMC Cancer 2017 17:475
    Content type: Study protocol Published on:

  19. CD133 (prominin-1) is widely believed to be a cancer stem cell marker in various solid tumor types, and CD133 has been correlated with tumor-initiating capacity. Recently, the nuclear location of CD133 express...

    Authors: Yao-Li Chen, Ping-Yi Lin, Ying-Zi Ming, Wei-Chieh Huang, Rong-Fu Chen, Po-Ming Chen and Pei-Yi Chu
    Citation: BMC Cancer 2017 17:474
    Content type: Research article Published on:

  21. Due to high mortality and lack of efficient screening, new tools for ovarian cancer (OC) diagnosis are urgently needed. To broaden the knowledge on the pathological processes that occur during ovarian cancer t...

    Authors: Agata Swiatly, Agnieszka Horala, Joanna Hajduk, Jan Matysiak, Ewa Nowak-Markwitz and Zenon J. Kokot
    Citation: BMC Cancer 2017 17:472
    Content type: Research article Published on:

  22. Although anaplastic lymphoma kinase (ALK) fusion genes are generally identified in lung adenocarcinoma patients, they are relatively rare in patients with squamous cell carcinoma (SqCC). Metastatic ALK-rearranged...

    Authors: Nobuaki Mamesaya, Kazuhisa Nakashima, Tateaki Naito, Takashi Nakajima, Masahiro Endo and Toshiaki Takahashi
    Citation: BMC Cancer 2017 17:471
    Content type: Case report Published on:

  23. According to the “fundamental cause” theory, emerging knowledge on health-enhancing behaviours and technologies results in health disparities. This study aims to assess (trends in) educational inequalities in ...

    Authors: Katrien Vanthomme, Hadewijch Vandenheede, Paulien Hagedoorn and Sylvie Gadeyne
    Citation: BMC Cancer 2017 17:470
    Content type: Research article Published on:

  24. DNA repair of alkylation damage is defective in various cancers. This occurs through somatically acquired inactivation of the MGMT gene in various cancer types, including breast cancers. In addition to MGMT, t...

    Authors: Olafur Andri Stefansson, Stefan Hermanowicz, Jasper van der Horst, Holmfridur Hilmarsdottir, Zuzanna Staszczak, Jon Gunnlaugur Jonasson, Laufey Tryggvadottir, Thorkell Gudjonsson and Stefan Sigurdsson
    Citation: BMC Cancer 2017 17:469
    Content type: Research article Published on:

  25. Secondary lymphedema of the upper and lower extremities related to prior oncologic therapies, including cancer surgeries, radiation therapy, and chemotherapy, is a major cause of long-term morbidity in cancer ...

    Authors: Ramon Garza III, Roman Skoracki, Karen Hock and Stephen P. Povoski
    Citation: BMC Cancer 2017 17:468
    Content type: Review Published on:

  27. Cancer patients are predominantly treated as out-patients and as they often experience difficult symptoms and side effects it is important to facilitate and improve patient-clinician communication to support s...

    Authors: Ann Langius-Eklöf, Marie-Therése Crafoord, Mats Christiansen, Maria Fjell and Kay Sundberg
    Citation: BMC Cancer 2017 17:466
    Content type: Study protocol Published on:

  28. Response to neoadjuvant chemoradiotherapy (CRT) of rectal cancer is variable. Accurate imaging for prediction and early assessment of response would enable appropriate stratification of management to reduce tr...

    Authors: Trang Thanh Pham, Gary Liney, Karen Wong, Robba Rai, Mark Lee, Daniel Moses, Christopher Henderson, Michael Lin, Joo-Shik Shin and Michael Bernard Barton
    Citation: BMC Cancer 2017 17:465
    Content type: Study protocol Published on:

  29. Previous nomograms for intrahepatic cholangiocarcinoma (ICC) were conducted to predict overall survival, which could be influenced by various factors. Herein, we conducted our nomogram to predict recurrence of...

    Authors: Seogsong Jeong, Qingbao Cheng, Lifeng Huang, Jian Wang, Meng Sha, Ying Tong, Lei Xia, Longzhi Han, Zhifeng Xi, Jianjun Zhang, Xiaoni Kong, Jinyang Gu and Qiang Xia
    Citation: BMC Cancer 2017 17:464
    Content type: Research article Published on:

  30. Uridine 5′-diphosphate-glucuronosyltransferase 2B (UGT2B) genes code for enzymes that catalyze the clearance of testosterone, dihydrotestosterone (DHT), and DHT metabolites in the prostate basal and luminal ti...

    Authors: Delores J. Grant, Zinan Chen, Lauren E. Howard, Emily Wiggins, Amanda De Hoedt, Adriana C. Vidal, Skyla T. Carney, Jill Squires, Clara E. Magyar, Jiaoti Huang and Stephen J. Freedland
    Citation: BMC Cancer 2017 17:463
    Content type: Research article Published on:

  31. In recent years, systemic chemotherapy and molecular targeted therapy have become standard first-line treatments for locally advanced or metastatic nonsquamous non-small cell lung cancer (NSCLC). The objective...

    Authors: Qing Zhou, Yong Song, Xin Zhang, Gong-Yan Chen, Dian-Sheng Zhong, Zhuang Yu, Ping Yu, Yi-Ping Zhang, Jian-Hua Chen, Yi Hu, Guo-Sheng Feng, Xia Song, Qiang Shi, Lu Lu Yang, Ping Hai Zhang and Yi-Long Wu
    Citation: BMC Cancer 2017 17:462
    Content type: Research article Published on:

  32. Elevated serum levels of luteinizing hormone and slightly decreased serum levels of testosterone (mild Leydig cell insufficiency) is a common hormonal disturbance in testicular cancer (TC) survivors. A number ...

    Authors: Mikkel Bandak, Niels Jørgensen, Anders Juul, Jakob Lauritsen, Michael Kreiberg, Peter Sandor Oturai, Jørn Wulff Helge and Gedske Daugaard
    Citation: BMC Cancer 2017 17:461
    Content type: Study protocol Published on:

  33. Histone deacetylase 6 (HDAC6) is a microtubule-associated deacetylase that promotes many cellular processes that lead to cell transformation and tumour development. We previously documented an interaction betw...

    Authors: Louisa M. Salemi, Matthew E. R. Maitland, Eyal R. Yefet and Caroline Schild-Poulter
    Citation: BMC Cancer 2017 17:460
    Content type: Research article Published on:

  34. Studies showed that axillary lymph node dissection can be safely omitted in presence of positive sentinel lymph node(s) in breast cancer patients treated with breast conserving therapy. Since the outcome of th...

    Authors: L. M. van Roozendaal, M. L. G. Vane, T. van Dalen, J. A. van der Hage, L. J. A. Strobbe, L. J. Boersma, S. C. Linn, M. B. I. Lobbes, P. M. P. Poortmans, V. C. G. Tjan-Heijnen, K. K. B. T. Van de Vijver, J. de Vries, A. H. Westenberg, A. G. H. Kessels, J. H. W. de Wilt and M. L. Smidt
    Citation: BMC Cancer 2017 17:459
    Content type: Study protocol Published on:

  35. miRNAs exert their effect through a negative regulatory mechanism silencing expression upon hybridizing to their target mRNA, and have a prominent position in the control of many cellular processes including c...

    Authors: Blanca Elena Castro-Magdonel, Manuela Orjuela, Javier Camacho, Adda Jeanette García-Chéquer, Lourdes Cabrera-Muñoz, Stanislaw Sadowinski-Pine, Noé Durán-Figueroa, María de Jesús Orozco-Romero, Ana Claudia Velázquez-Wong, Adriana Hernández-Ángeles, Claudia Hernández-Galván, Citlali Lara-Molina and M. Verónica Ponce-Castañeda
    Citation: BMC Cancer 2017 17:458
    Content type: Research article Published on:

  36. Sequencing analysis of circulating tumor cells (CTCs) enables “liquid biopsy” to guide precision oncology strategies. However, this requires low-template whole genome amplification (WGA) that is prone to error...

    Authors: Shonan Sho, Colin M. Court, Paul Winograd, Sangjun Lee, Shuang Hou, Thomas G. Graeber, Hsian-Rong Tseng and James S. Tomlinson
    Citation: BMC Cancer 2017 17:457
    Content type: Research article Published on:

  37. Hormonal therapy is used as a treatment option in high-grade ovarian carcinoma (HGOC), but the role and choice of treatment remains unclear. Agents used include tamoxifen and aromatase inhibitors. Our aim was ...

    Authors: Angela George, Jennifer McLachlan, Nina Tunariu, Chiara Della Pepa, Cristina Migali, Martin Gore, Stan Kaye and Susana Banerjee
    Citation: BMC Cancer 2017 17:456
    Content type: Research article Published on:

  39. The pathological and oncological outcomes of retro-pubic radical prostatectomy (RRP) and robot-assisted radical prostatectomy (RARP) have not been sufficiently investigated.

    Authors: Tetsuya Fujimura, Hiroshi Fukuhara, Satoru Taguchi, Yuta Yamada, Toru Sugihara, Tohru Nakagawa, Aya Niimi, Haruki Kume, Yasuhiko Igawa and Yukio Homma
    Citation: BMC Cancer 2017 17:454
    Content type: Research article Published on:

  40. We describe a randomized, non-blinded Phase II interventional study to assess the safety and efficacy of stereotactic ablative radiotherapy (SABR) for hormone-sensitive oligometastatic prostate adenocarcinoma,...

    Authors: Noura Radwan, Ryan Phillips, Ashley Ross, Steven P. Rowe, Michael A. Gorin, Emmanuel S. Antonarakis, Curtiland Deville, Stephen Greco, Samuel Denmeade, Channing Paller, Daniel Y. Song, Maximilian Diehn, Hao Wang, Michael Carducci, Kenneth J. Pienta, Martin G. Pomper…
    Citation: BMC Cancer 2017 17:453
    Content type: Study protocol Published on:

  42. Recognizing resistance or susceptibility to the current standard cisplatin and paclitaxel treatment could improve therapeutic outcomes of metastatic or recurrent cervical cancer.

    Authors: Sofia Karageorgopoulou, Ioannis D. Kostakis, Maria Gazouli, Sonia Markaki, Marios Papadimitriou, Evangelos Bournakis, Meletios-Athanassios Dimopoulos and Christos A Papadimitriou
    Citation: BMC Cancer 2017 17:451
    Content type: Research article Published on:

  43. Neoadjuvant chemoradiation is not recommended as an approach for treatment of esophageal squamous cell carcinoma due to its significant postoperative mortality. However, it is assumed the combination of neoadj...

    Authors: Han Tang, Lijie Tan, Yaxing Shen, Hao Wang, Miao Lin, Mingxiang Feng, Songtao Xu, Weigang Guo, Cheng Qian, Tianshu Liu, Zhaochong Zeng, Yingyong Hou, Zhentao Yu, Hongjing Jiang, Zhigang Li, Chun Chen…
    Citation: BMC Cancer 2017 17:450
    Content type: Study protocol Published on:

  44. Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies in China and is an exceptionally drug-resistant tumor with a 5-year survival rate less than 15%. Cisplatin is the most commonly ...

    Authors: Xinfang Yu, Wei Li, Zhenkun Xia, Li Xie, Xiaolong Ma, Qi Liang, Lijun Liu, Jian Wang, Xinmin Zhou, Yifeng Yang and Haidan Liu
    Citation: BMC Cancer 2017 17:449
    Content type: Research article Published on:

  45. Better surgical techniques, chemotherapy and biological therapy have improved survival in patients with colorectal cancer (CRC), most markedly in younger patients. About half of patients over 70 years receive ...

    Authors: C. M. Lund, K. K. Vistisen, C. Dehlendorff, F. Rønholt, J. S. Johansen and D. L. Nielsen
    Citation: BMC Cancer 2017 17:448
    Content type: Study protocol Published on:

  46. Epithelial to mesenchymal transition (EMT) is the process by which stationary epithelial cells transdifferentiate to mesenchymal cells with increased motility. EMT is integral in early stages of development an...

    Authors: Princy Parsana, Sarah R. Amend, James Hernandez, Kenneth J. Pienta and Alexis Battle
    Citation: BMC Cancer 2017 17:447
    Content type: Research article Published on:

  47. Cancer and cancer treatment coincide with substantial negative physical, psychological and psychosocial problems. Physical activity (PA) can positively affect the negative effects of cancer and cancer treatmen...

    Authors: R. H. J. Golsteijn, C. Bolman, E. Volders, D. A. Peels, H. de Vries and L. Lechner
    Citation: BMC Cancer 2017 17:446
    Content type: Study protocol Published on:

  48. Transoral videolaryngoscopic surgery (TOVS) was developed as a new distinct surgical procedure for hypopharyngeal cancer (HPC) and supraglottic cancer (SGC) staged at up to T3. However, long-term treatment out...

    Authors: Yorihisa Imanishi, Hiroyuki Ozawa, Koji Sakamoto, Ryoichi Fujii, Seiji Shigetomi, Noboru Habu, Kuninori Otsuka, Yoichiro Sato, Yoshihiro Watanabe, Mariko Sekimizu, Fumihiro Ito, Toshiki Tomita and Kaoru Ogawa
    Citation: BMC Cancer 2017 17:445
    Content type: Research article Published on:

  49. Patients with type 2 diabetes (T2D) are at increased risk for developing cancer. As approximately 8% of the world’s population is living with T2D, even a slight increase in cancer risk could result in an enorm...

    Authors: Dennis Schrijnders, Geertruida H. de Bock, Sebastiaan T. Houweling, Kornelis J. J. van Hateren, Klaas H. Groenier, Jeffrey A. Johnson, Henk J. G. Bilo, Nanne Kleefstra and Gijs W. D. Landman
    Citation: BMC Cancer 2017 17:444
    Content type: Study protocol Published on:

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