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  1. Genetic predisposition is the primary risk factor for familial breast cancer. For the majority of familial breast cancer, however, the genetic predispositions remain unknown. All newly identified predispositio...

    Authors: Hongxiu Wen, Yeong C Kim, Carrie Snyder, Fengxia Xiao, Elizabeth A Fleissner, Dina Becirovic, Jiangtao Luo, Bradley Downs, Simon Sherman, Kenneth H Cowan, Henry T Lynch and San Ming Wang
    Citation: BMC Cancer 2014 14:470
    Content type: Research article Published on:

  2. Breast cancer affects one in eight UK women during their lifetime: many of these women now receive adjuvant chemotherapy and hormone therapy. Joint and muscle pains, aches, and stiffness are common but the nat...

    Authors: Deborah Fenlon, Cassandra Powers, Peter Simmonds, Joanne Clough and Julia Addington-Hall
    Citation: BMC Cancer 2014 14:467
    Content type: Research article Published on:

  3. Recent work led to recognize sessile serrated adenomas (SSA) as precursor to many of the sporadic colorectal cancers with microsatellite instability (MSI). However, comprehensive analyses of DNA methylation in...

    Authors: Yuta Muto, Takafumi Maeda, Koichi Suzuki, Takaharu Kato, Fumiaki Watanabe, Hidenori Kamiyama, Masaaki Saito, Kei Koizumi, Yuichiro Miyaki, Fumio Konishi, Sergio Alonso, Manuel Perucho and Toshiki Rikiyama
    Citation: BMC Cancer 2014 14:466
    Content type: Research article Published on:

  5. The goal of this study was to determine the prognostic factors associated with an improved overall outcome after stereotactic body radiotherapy (SBRT) for primary lung cancer and metastatic lung tumors.

    Authors: Takaya Yamamoto, Keiichi Jingu, Yuko Shirata, Masashi Koto, Haruo Matsushita, Toshiyuki Sugawara, Masaki Kubozono, Rei Umezawa, Keiko Abe, Noriyuki Kadoya, Youjirou Ishikawa, Maiko Kozumi, Noriyoshi Takahashi, Ken Takeda and Yoshihiro Takai
    Citation: BMC Cancer 2014 14:464
    Content type: Research article Published on:

  6. Aberrantly activated Notch signaling has been found in more than 50% of patients with T-cell acute lymphoblastic leukemia (T-ALL). Current strategies that employ γ-secretase inhibitors (GSIs) to target Notch a...

    Authors: Wei Fu, Kai Wang, Jun-Long Zhao, Heng-Chao Yu, San-Zhong Li, Yan Lin, Liang Liang, Si-Yong Huang, Ying-Min Liang, Hua Han and Hong-Yan Qin
    Citation: BMC Cancer 2014 14:463
    Content type: Research article Published on:

  7. Bortezomib offers a novel approach to the treatment of multiple myeloma producing rapid control. The aim of this study was to investigate the outcomes of bortezomib and dexamethasone-treated patients with mult...

    Authors: Takayoshi Kiba, Takuo Ito, Toshihisa Nakashima, Yoshiko Okikawa, Miki Kido, Akiko Kimura, Keita Kameda, Fumiaki Miyamae, Suzuko Tanaka, Misao Atsumi, Yoko Sumitani, Yoshimi Shitakubo and Hiromasa Niimi
    Citation: BMC Cancer 2014 14:462
    Content type: Research article Published on:

  8. Kinesin family member 2a (KIF2A), a type of motor protein found in eukaryotic cells, is associated with development and progression of various human cancers. The role of KIF2A during breast cancer tumorigenesi...

    Authors: Jianli Wang, Siqin Ma, Rong Ma, Xun Qu, Wenjun Liu, Cuixia Lv, Song Zhao and Yunyun Gong
    Citation: BMC Cancer 2014 14:461
    Content type: Research article Published on:

  9. The combination of virotherapy and chemotherapy may enable efficient tumor regression that would be unachievable using either therapy alone. In this study, we investigated the efficiency of transgene delivery ...

    Authors: Anna Zajakina, Jelena Vasilevska, Dmitry Zhulenkovs, Dace Skrastina, Artjoms Spaks, Aiva Plotniece and Tatjana Kozlovska
    Citation: BMC Cancer 2014 14:460
    Content type: Research article Published on:

  10. Expression of integrin α3β1 is associated with tumor progression, metastasis, and poor prognosis in several cancers, including breast cancer. Moreover, preclinical studies have revealed important pro-tumorigen...

    Authors: Anshu Aggarwal, Rami N Al-Rohil, Anupam Batra, Paul J Feustel, David M Jones and C Michael DiPersio
    Citation: BMC Cancer 2014 14:459
    Content type: Research article Published on:

  11. Overexpression of cyclooxygenase-2 (COX-2) has been implicated in oncogenesis and progression of adenocarcinomas of the pancreatic head. The data on the prognostic importance of COX expression in these tumours...

    Authors: Ewa Pomianowska, Aasa R Schjølberg, Ole Petter F Clausen and Ivar P Gladhaug
    Citation: BMC Cancer 2014 14:458
    Content type: Research article Published on:

  12. Prostate tumor overexpressed 1 (PTOV1) was demonstrated to play an important role in cancer progression and was correlated with unfavorable clinical outcome. However, the clinical role of PTOV1 in cancer remai...

    Authors: Fangyong Lei, Longjuan Zhang, Xinghua Li, Xi Lin, Shu Wu, Fengyan Li and Junling Liu
    Citation: BMC Cancer 2014 14:457
    Content type: Research article Published on:

  13. Therapeutic decisions in cancer are generally guided by molecular biomarkers or, for some newer therapeutics, primary tumor genotype. However, because biomarkers or genotypes may change as new metastases emerg...

    Authors: Glenn Deng, Sujatha Krishnakumar, Ashley A Powell, Haiyu Zhang, Michael N Mindrinos, Melinda L Telli, Ronald W Davis and Stefanie S Jeffrey
    Citation: BMC Cancer 2014 14:456
    Content type: Research article Published on:

  14. Clear cell sarcoma (CCS) is a therapeutically unresolved, aggressive, soft tissue sarcoma (STS) that predominantly affects young adults. This sarcoma is defined by t(12;22)(q13;q12) translocation, which leads ...

    Authors: Hidetatsu Outani, Takaaki Tanaka, Toru Wakamatsu, Yoshinori Imura, Kenichiro Hamada, Nobuhito Araki, Kazuyuki Itoh, Hideki Yoshikawa and Norifumi Naka
    Citation: BMC Cancer 2014 14:455
    Content type: Research article Published on:

  15. Cancer remains the second leading cause of mortality in the United States. Special events such as health fairs, screening days or cultural festivals are employed often for community education about cancer scre...

    Authors: Cam Escoffery, Kirsten C Rodgers, Michelle C Kegler, Mary Ayala, Erika Pinsker and Regine Haardörfer
    Citation: BMC Cancer 2014 14:454
    Content type: Research article Published on:

  16. 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) is a well-established imaging modality for a wide variety of solid malignancies. Currently, only limited data exists reg...

    Authors: Stephen P Povoski, Douglas A Murrey Jr, Sabrina M Smith, Edward W Martin Jr and Nathan C Hall
    Citation: BMC Cancer 2014 14:453
    Content type: Research article Published on:

  17. Glioma is the most common primary malignant central nervous system tumor in adult, and is usually not curable due to its invasive nature. Establishment of serum biomarkers for glioma would be beneficial both f...

    Authors: Masayo Adachi-Hayama, Akihiko Adachi, Natsuki Shinozaki, Tomoo Matsutani, Takaki Hiwasa, Masaki Takiguchi, Naokatsu Saeki and Yasuo Iwadate
    Citation: BMC Cancer 2014 14:452
    Content type: Research article Published on:

  18. HIV infection leads to a decreasing immune response, thereby facilitating the appearance of other infections, one of the most important ones being HPV. However, studies are needed for determining associations ...

    Authors: Milena Camargo, Sara C Soto-De Leon, Marina Munoz, Ricardo Sanchez, Diego Peña-Herrera, Andrea Clemencia Pineda-Peña, Otto Sussmann, Carol Paez, Antonio Perez-Prados, Manuel Elkin Patarroyo and Manuel Alfonso Patarroyo
    Citation: BMC Cancer 2014 14:451
    Content type: Research article Published on:

  20. Glioblastomas are largely unresponsive to all available treatments and there is therefore an urgent need for novel therapeutics. Here we have probed the antineoplastic effects of a bacterial protein toxin, the...

    Authors: Eleonora Vannini, Anna Panighini, Chiara Cerri, Alessia Fabbri, Simonetta Lisi, Enrico Pracucci, Nicola Benedetto, Riccardo Vannozzi, Carla Fiorentini, Matteo Caleo and Mario Costa
    Citation: BMC Cancer 2014 14:449
    Content type: Research article Published on:

  21. MicroRNAs (miRs) represent a distinct class of posttranscriptional modulators of gene expression with remarkable stability in sera. Several miRs are oncogenic (oncomiRs) and are deregulated in the pathogenesis...

    Authors: Marek Sochor, Petra Basova, Michal Pesta, Nina Dusilkova, Jiri Bartos, Pavel Burda, Vit Pospisil and Tomas Stopka
    Citation: BMC Cancer 2014 14:448
    Content type: Research article Published on:

  22. In this study, high risk clinical target volumes (HR-CTVs) according to GEC-ESTRO guideline were contoured retrospectively based on CT images taken at the time of high-dose rate intracavitary brachytherapy (HD...

    Authors: Naoya Murakami, Takahiro Kasamatsu, Akihisa Wakita, Satoshi Nakamura, Hiroyoki Okamoto, Koji Inaba, Madoka Morota, Yoshinori Ito, Minako Sumi and Jun Itami
    Citation: BMC Cancer 2014 14:447
    Content type: Research article Published on:

  23. Colorectal cancer is the third most commonly diagnosed cancer worldwide. Few studies have addressed the causes and risks of treatment refusal in a universal health insurance setting.

    Authors: Chun-Yi Liu, William Tzu-Liang Chen, Pei-Tseng Kung, Chang-Fang Chiu, Yueh-Hsin Wang, Shwn-Huey Shieh and Wen-Chen Tsai
    Citation: BMC Cancer 2014 14:446
    Content type: Research article Published on:

  24. There is evidence, although inconsistent, that long term exposure to disinfection by products (DBPs) increases the risk of bowel cancer. No study has been conducted in Australia to examine this association and...

    Authors: Md Bayzidur Rahman, Christine Cowie, Tim Driscoll, Richard J Summerhayes, Bruce K Armstrong and Mark S Clements
    Citation: BMC Cancer 2014 14:445
    Content type: Research article Published on:

  25. Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) has been identified as a putative cancer stem cell (CSC) marker in breast cancer. However, the clinicopathological and prognostic significance of this protei...

    Authors: Ying Liu, Dong-lai Lv, Jiang-jie Duan, Sen-lin Xu, Jing-fang Zhang, Xiao-jun Yang, Xia Zhang, You-hong Cui, Xiu-wu Bian and Shi-cang Yu
    Citation: BMC Cancer 2014 14:444
    Content type: Research article Published on:

  27. Tumor invasion and metastasis represent a major unsolved problem in cancer pathogenesis. Recent studies have indicated the involvement of Src-homology 2 domain-containing tyrosine phosphatase 2 (SHP2) in multi...

    Authors: Hsueh-Chun Wang, Wei-Fan Chiang, Hsin-Hsiu Huang, Ying-Ying Shen and Hung-Che Chiang
    Citation: BMC Cancer 2014 14:442
    Content type: Research article Published on:

  28. FOLFOX second-line treatment seems to be a validated option for patients with pancreatic cancer (PC) progressing after gemcitabine chemotherapy. However, other therapeutics strategy has developed in first-line...

    Authors: Aziz Zaanan, Isabelle Trouilloud, Theofano Markoutsaki, Mélanie Gauthier, Anne-Claire Dupont-Gossart, Thierry Lecomte, Thomas Aparicio, Pascal Artru, Anne Thirot-Bidault, Fanny Joubert, Daniella Fanica and Julien Taieb
    Citation: BMC Cancer 2014 14:441
    Content type: Research article Published on:

  29. MicroRNAs (miRNAs) are frequently dysregulated in human cancers and can act as either potent oncogenes or tumor suppressor genes. In the present study, we intend to prove that the gene PTEN (phosphatase and te...

    Authors: Guiyu Zhang, Xinxin Hou, Yue Li and Meng Zhao
    Citation: BMC Cancer 2014 14:440
    Content type: Research article Published on:

  30. Cancer of unknown primary (CUP) is a fatal cancer, accounting for 3–5% of all diagnosed cancers. Finding the primary site is important for therapeutic choices and we believe that the organ which is designated ...

    Authors: Matias Riihimäki, Akseli Hemminki, Kristina Sundquist and Kari Hemminki
    Citation: BMC Cancer 2014 14:439
    Content type: Research article Published on:

  31. The global burden from cancer is rising, especially as low-income countries like Bangladesh observe rapid aging. So far, there are no comprehensive descriptions reporting diagnosed cancer group that include he...

    Authors: Mohammad Sorowar Hossain, Mohd S Iqbal, Mohiuddin Ahmed Khan, Mohammad Golam Rabbani, Hazera Khatun, Sirajam Munira, M Morshed Zaman Miah, Amin Lutful Kabir, Naima Islam, Tashmim Farhana Dipta, Farzana Rahman, Abdul Mottalib, Salma Afrose, Tasneem Ara, Akhil Ranjan Biswas, Mizanur Rahman…
    Citation: BMC Cancer 2014 14:438
    Content type: Research article Published on:

  32. The aim of this study was to evaluate the efficacy of the p53-reactivating drugs RITA and nutlin3a in killing myeloma cells.

    Authors: Sylvanie Surget, Géraldine Descamps, Carole Brosseau, Vincent Normant, Sophie Maïga, Patricia Gomez-Bougie, Nadège Gouy-Colin, Catherine Godon, Marie C Béné, Philippe Moreau, Steven Le Gouill, Martine Amiot and Catherine Pellat-Deceunynck
    Citation: BMC Cancer 2014 14:437
    Content type: Research article Published on:

  33. Heme oxygenase-1 (HO-1) and its major product carbon monoxide (CO) are known to be involved in the development and progression of many tumors. The present study was to elucidate the expression and function of ...

    Authors: Hongzhuan Yin, Jun Fang, Long Liao, Hiroshi Maeda and Qi Su
    Citation: BMC Cancer 2014 14:436
    Content type: Research article Published on:

  34. Tyrosine phosphorylation (pTyr) is an important cancer relevant posttranslational modification since it regulates protein activity and cellular localization. By controlling cell growth and differentiation it p...

    Authors: Lioudmila Elfineh, Christina Classon, Anna Asplund, Ulf Pettersson, Masood Kamali-Moghaddam and Sara Bergström Lind
    Citation: BMC Cancer 2014 14:435
    Content type: Research article Published on:

  35. Mutations in NBN, the gene for Nijmegen Breakage Syndrome (NBS), are thought to predispose women to developing breast cancer, but a breast cancer cell line containing mutations in NBN has not yet been describe...

    Authors: Bianca Schröder-Heurich, Natalia Bogdanova, Britta Wieland, Xiaoxi Xie, Monika Noskowicz, Tjoung-Won Park-Simon, Peter Hillemanns, Hans Christiansen and Thilo Dörk
    Citation: BMC Cancer 2014 14:434
    Content type: Research article Published on:

  36. Especially in human tumor cells, the osteopontin (OPN) primary transcript is subject to alternative splicing, generating three isoforms termed OPNa, OPNb and OPNc. We previously demonstrated that the OPNc spli...

    Authors: Tatiana M Tilli, Akeila Bellahcène, Vincent Castronovo and Etel R P Gimba
    Citation: BMC Cancer 2014 14:433
    Content type: Research article Published on:

  37. Oral squamous cell carcinoma is an aggressive neoplasm with serious morbidity and mortality, which typically spreads through local invasive growth. Lysophosphatidic acid (LPA) is involved in a number of biolog...

    Authors: Ingvild J Brusevold, Ingun H Tveteraas, Monica Aasrum, John Ødegård, Dagny L Sandnes and Thoralf Christoffersen
    Citation: BMC Cancer 2014 14:432
    Content type: Research article Published on:

  38. A common approach to cancer therapy in clinical practice is the combination of several drugs to boost the anticancer activity of available drugs while suppressing their unwanted side effects. In this regard, w...

    Authors: Hye-Kyung Park, Ji-Eun Lee, Jaehwa Lim, Da-Eun Jo, Soo-Ah Park, Pann-Ghill Suh and Byoung Heon Kang
    Citation: BMC Cancer 2014 14:431
    Content type: Research article Published on:

  39. Tumorigenesis is the result of genomic or epigenomic insults and subsequent loss of the proper mechanisms to respond to these alterations leading to unscheduled growth. Tumors arising from these mutations ofte...

    Authors: William N Pappano, Qian Zhang, Lora A Tucker, Chris Tse and Jieyi Wang
    Citation: BMC Cancer 2014 14:430
    Content type: Research article Published on:

  40. Hypoxia is often encountered in solid tumors and known to contribute to aggressive tumor behavior, radiation- and chemotherapy resistance resulting in a poor prognosis for the cancer patient. MicroRNAs (miRNAs...

    Authors: Caroline MM Gits, Patricia F van Kuijk, Jonneke CWM de Rijck, Nikky Muskens, Moniek BE Jonkers, Wilfred F van IJcken, Ron HJ Mathijssen, Jaap Verweij, Stefan Sleijfer and Erik AC Wiemer
    Citation: BMC Cancer 2014 14:429
    Content type: Research article Published on:

  41. Cancer survivorship rates have increased in developed countries largely due to population ageing and improvements in cancer care. Survivorship is a neglected phase of cancer treatment and is often associated w...

    Authors: Lauren J Frensham, Dorota M Zarnowiecki, Gaynor Parfitt, Rebecca M Stanley and James Dollman
    Citation: BMC Cancer 2014 14:428
    Content type: Study protocol Published on:

  42. Survival is poorer in elderly patients with head and neck squamous cell carcinomas [HNSCCs] than in younger patients. Possible explanations include a contribution of co-morbidities to mortality, frequent refus...

    Authors: Lydia Brugel, Marie Laurent, Philippe Caillet, Anne Radenne, Isabelle Durand-Zaleski, Michel Martin, Melany Baron, Héloïse de Kermadec, Sylvie Bastuji-Garin, Florence Canouï-Poitrine and Elena Paillaud
    Citation: BMC Cancer 2014 14:427
    Content type: Study protocol Published on:

  43. Breast cancer is one of the most deadly diseases in women. Inhibiting the synthesis of estrogen is effective in treating patients with estrogen-responsive breast cancer. Previous studies have demonstrated that...

    Authors: Tsz Yan Wong, Fengjuan Li, Shu-mei Lin, Franky L Chan, Shiuan Chen and Lai K Leung
    Citation: BMC Cancer 2014 14:426
    Content type: Research article Published on:

  44. 14-3-3σ is implicated in promoting tumor development of various malignancies. However, the clinical relevance of 14-3-3σ in hepatocellular carcinoma (HCC) tumor progression and modulation and pathway elucidati...

    Authors: Chia-Chia Liu, Yee-Jee Jan, Bor-Sheng Ko, Yao-Ming Wu, Shu-Man Liang, Shyh-Chang Chen, Yen-Ming Lee, Tzu-An Liu, Tzu-Ching Chang, John Wang, Song-Kun Shyue, Li-Ying Sung and Jun-Yang Liou
    Citation: BMC Cancer 2014 14:425
    Content type: Research article Published on:

  45. Ovarian cancer is the most lethal gynecologic malignancy, but its etiology remains poorly understood. This study investigated the role of Fli-1 in ovarian carcinogenesis and disease survival.

    Authors: Wei Song, Lingyun Hu, Wei Li, Guanjun Wang, Yan Li, Lei Yan, Ailing Li and Jiuwei Cui
    Citation: BMC Cancer 2014 14:424
    Content type: Research article Published on:

  46. New effective treatments for metastatic melanoma greatly improve survival in a proportion of patients. However biomarkers to identify patients that are more likely to benefit from a particular treatment are ne...

    Authors: Dragana Klinac, Elin S Gray, James B Freeman, Anna Reid, Samantha Bowyer, Michael Millward and Melanie Ziman
    Citation: BMC Cancer 2014 14:423
    Content type: Research article Published on:

  47. To compare survival of patients with non-small cell lung cancer (NSCLC) who underwent surgical resection and lymph node sampling based on guidelines proposed by the American College of Surgeons Oncology Group ...

    Authors: Dongsheng Yue, Liqun Gong, Jian You, Yanjun Su, Zhenfa Zhang, Zhen Zhang, Feng Gu, Meng Wang and Changli Wang
    Citation: BMC Cancer 2014 14:422
    Content type: Research article Published on:

  48. In the Republic of Korea, cancer is the most common cause of death, and cancer incidence and mortality rates are the highest in East Asia. As alcoholic beverages are carcinogenic to humans, we estimated the bu...

    Authors: Sohee Park, Hai-Rim Shin, Boram Lee, Aesun Shin, Kyu-Won Jung, Duk-Hee Lee, Sun Ha Jee, Sung-Il Cho, Sue Kyung Park, Mathieu Boniol, Paolo Boffetta and Elisabete Weiderpass
    Citation: BMC Cancer 2014 14:420
    Content type: Research article Published on:

  49. Cervical carcinoma is the second most common cancer and is an important cause of death in women worldwide. CCAAT/enhancer binding proteins (C/EBPs) are a family of transcription factors that regulate cellular ...

    Authors: Zemin Pan, Weinan Zheng, Jinli Zhang, Rui Gao, Dongmei Li, Xiaoqing Guo, Hu Han, Feng Li, Shen Qu and Renfu Shao
    Citation: BMC Cancer 2014 14:417
    Content type: Research article Published on:

  50. In non-small cell lung cancer patients (NSCLC), median survival from the time patients develop bone metastasis is classically described being inferior to 6 months. We investigated the subcategory of patients h...

    Authors: Mélanie Deberne, Stanislas Ropert, Bertrand Billemont, Catherine Daniel, Jeanne Chapron and François Goldwasser
    Citation: BMC Cancer 2014 14:416
    Content type: Research article Published on:

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