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  1. Osteosarcoma (OS) is one of the most common aggressive bone malignancy tumors in adolescents. With the application of new chemotherapy regimens, finding new and effective anti-OS drugs to coordinate program im...

    Authors: Feifan Zhang, Yang Hao, Ning Yang, Man Liu, Yage Luo, Ying Zhang, Jian Zhou, Hongjian Liu and Jitian Li
    Citation: BMC Cancer 2024 24:198
    Content type: Research Published on:

  2. The superior efficacy of concurrent thoracic radiotherapy (TRT) and epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) has been proven in locally advanced and advanced non-small cell lung ...

    Authors: Hanjing Yin, Wenxiao Jia, Jinming Yu and Hui Zhu
    Citation: BMC Cancer 2024 24:197
    Content type: Research Published on:

  3. Studies have shown that the absolute lymphocyte count (ALC) and the neutrophil-to-lymphocyte ratio (NLR) are related to the outcomes in patients with breast cancer receiving specific chemotherapies. However, t...

    Authors: Meng-Xia Su, Hsiang-Wen Lin, Hanh T. H. Nguyen, Tien-Chao Lin, Chih-Jung Chen, Hwei-Chung Wang, Chen-Teng Wu, Yao-Chung Wu, Geng-Yan He, Liang-Chih Liu and Chih-Hao Huang
    Citation: BMC Cancer 2024 24:195
    Content type: Research Published on:

  4. Hepatocellular carcinoma (HCC) is the most common type of malignant liver tumor with poor prognosis. In this study, we investigated the expression of transforming growth factor beta regulator 4 (TBRG4) in HCC ...

    Authors: Shanchun Tao, Di Cui, Huimin Cheng, Xiaofei Liu, Zhaobin Jiang, Hongwei Chen and Yong Gao
    Citation: BMC Cancer 2024 24:194
    Content type: Research Published on:

  5. Prognosis prediction for pancreatic cancer has always been difficult in clinical practice because of its high heterogeneity and mortality. The aim of the study was to assess the value of prognostic immune-infl...

    Authors: Jie Yang, Hongkun Zhou, Huangbao Li, Fengqing Zhao and Kun Tong
    Citation: BMC Cancer 2024 24:193
    Content type: Research Published on:

  6. Recent advances in the management of pancreatic neuroendocrine tumors (pNETs) highlight the potential benefits of temozolomide, an alkylating agent, for these patients. In this meta-analysis, we aimed to asses...

    Authors: Erfan Taherifard, Muhammad Bakhtiar, Mahnoor Mahnoor, Rabeea Ahmed, Ludimila Cavalcante, Janie Zhang and Anwaar Saeed
    Citation: BMC Cancer 2024 24:192
    Content type: Systematic Review Published on:

  7. Cancer is a significant public health concern and the second leading cause of death. This study aims to visualize spatial patterns of top common cancer types and identify high-risk and low-risk counties for th...

    Authors: Sharareh Faramarzi, Behzad Kiani, Shahla Faramarzi and Neda Firouraghi
    Citation: BMC Cancer 2024 24:191
    Content type: Research Published on:

  8. Histiocytoses are rare disorders manifested by increased proliferation of pathogenic myeloid cells sharing histological features with macrophages or dendritic cells and accumulating in various organs, i.a., bo...

    Authors: Agnieszka Śmieszek, Klaudia Marcinkowska, Zofia Małas, Mateusz Sikora, Martyna Kępska, Beata A. Nowakowska, Marta Deperas, Marta Smyk, Carlos Rodriguez-Galindo and Anna Raciborska
    Citation: BMC Cancer 2024 24:105
    Content type: Research Published on:

  9. The purpose of this propensity score matching (PSM) analysis was to compare the effects of preoperative transcatheter arterial chemoembolization (TACE) and non-TACE on the long-term survival of patients who un...

    Authors: Run Hu, Jie Xu, Hongxiang Wang, Jiaguo Wang, Kai Lei, Xiaoping Zhao, Huizhi Zhang, Ke You and Zuojin Liu
    Citation: BMC Cancer 2024 24:190
    Content type: Research Published on:

  10. The partitioned survival model (PSM) and the state transition model (STM) are widely used in cost-effectiveness analyses of anticancer drugs. Using different modeling approaches with or without consideration o...

    Authors: Yoon-Bo Shim, Byeong-Chan Oh, Eui-Kyung Lee and Mi-Hai Park
    Citation: BMC Cancer 2024 24:189
    Content type: Research Published on:

  11. There is limited evidence of comparative results among different treatments regarding impacts of Health-Related Quality of Life (HRQoL) for patients with metastatic colorectal cancer (mCRC). We aimed to compar...

    Authors: Yunlin Jiang, Mingye Zhao, Wenxi Tang and Xueping Zheng
    Citation: BMC Cancer 2024 24:188
    Content type: Research Published on:

  13. To compare the efficacy, safety and effects on quality of life of different ALK-inhibitors for global and Asian patients with advanced ALK-positive non-small-cell lung cancer (NSCLC).

    Authors: Mingye Zhao, Taihang Shao, Hanqiao Shao, Caicun Zhou and Wenxi Tang
    Citation: BMC Cancer 2024 24:186
    Content type: Research Published on:

  14. Predicting tumor responses to neoadjuvant chemotherapy (NAC) is critical for evaluating prognosis and designing treatment strategies for patients with breast cancer; however, there are no reliable biomarkers t...

    Authors: Min Woo Kim, Hyojung Lee, Suji Lee, Sol Moon, Young Kim, Joon Ye Kim, Seung Il Kim and Jee Ye Kim
    Citation: BMC Cancer 2024 24:185
    Content type: Research Published on:

  15. Sinonasal mucosal melanoma (SNMM) is a relatively rare malignant tumour with a poor prognosis. This study was designed to identify prognostic factors and establish a nomogram model to predict the overall survi...

    Authors: Zhenzhen Zhu, Weiqing Wang, Yang Zha, Xiaowei Wang, Surita Aodeng, Lei Wang, Yuzhuo Liu and Wei Lv
    Citation: BMC Cancer 2024 24:184
    Content type: Research Published on:

  16. Lung cancer (LC) has poor survival outcomes mainly due to diagnosis at late stages. This study explored the anticipated time to seek medical advice for possible LC symptoms and barriers to early presentation i...

    Authors: Mohamedraed Elshami, Nawras Sawafta, Ahmad Mansour, Mohammed Alser, Ibrahim Al-Slaibi, Hanan Abukmail, Hanan Shurrab, Shahd Qassem, Faten Darwish Usrof, Malik Alruzayqat, Wafa Aqel, Roba Nairoukh, Rahaf Kittaneh, Yousef Mahmoud Nimer Habes, Obaida Ghanim, Wesam Almajd Aabed…
    Citation: BMC Cancer 2024 24:183
    Content type: Research Published on:

  17. Breast cancer (BC) is the second-leading factor of mortality for women globally and is brought on by a variety of genetic and environmental causes. The conventional treatments for this disease have limitations...

    Authors: Ying Jiang, Jiayu Liu, Lingyan Chen, Zhiwen Qian and Yan Zhang
    Citation: BMC Cancer 2024 24:182
    Content type: Review Published on:

  18. In this meta-analysis, we conducted a comparative analysis of the safety and efficacy of hypofractionated and conventional fractionated radiotherapy in individuals who had undergone surgery for breast cancer.

    Authors: Yongkai Lu, Beina Hui, Di Yang, Yi Li, Binglin Li, Luping Zhou, Lei Xu, Fengwen Tang, Wei Wang, Ruijuan Chen and Dongli Zhao
    Citation: BMC Cancer 2024 24:181
    Content type: Research Published on:

  20. Men with breast cancer experience unique physical and emotional challenges. However, a thorough understanding of these experiences including the psychosocial effects and supportive care needs have received les...

    Authors: Mary Abboah-Offei, Jonathan Bayuo, Yakubu Salifu, Oladayo Afolabi and Theophilus N. Akudjedu
    Citation: BMC Cancer 2024 24:179
    Content type: Research Published on:

  22. Neoadjuvant chemoradiotherapy (nCRT) and surgery have been recommended as the standard treatments for locally advanced esophageal squamous cell carcinoma (ESCC). In addition, nodal metastases decreased in freq...

    Authors: Run-Da Lu, Zheng-Dao Wei, Yi-Xin Liu, Dong Tian, Han-Lu Zhang, Qi-Xin Shang, Wei-Peng Hu, Lin Yang, Yu-Shang Yang and Long-Qi Chen
    Citation: BMC Cancer 2024 24:177
    Content type: Research Published on:

  23. This study aimed to evaluate the efficacy and side effects of first-line afatinib treatment in a real-world setting in Vietnam.

    Authors: Cam Phuong Pham, Thi Thai Hoa Nguyen, Anh Tu Do, Tuan Khoi Nguyen, Thi Anh Thu Hoang, Tuan Anh Le, Dinh Thy Hao Vuong, Dac Nhan Tam Nguyen, Van Khiem Dang, Thi Oanh Nguyen, Van Luan Pham, Minh Hai Nguyen, Thi Huyen Trang Vo, Hung Kien Do, Ha Thanh Vu, Thi Thuy Hang Nguyen…
    Citation: BMC Cancer 2024 24:176
    Content type: Research Published on:

  24. Targeted drugs are the main methods of RCC treatment. However, drug resistance is common in RCC patients, in-depth study of the drug-resistant mechanism is essential.

    Authors: Fangzhen Cai, Jianwei Li, Yanmei Zhang, Sihuai Huang, Wenbin Liu, Weifeng Zhuo and Chengzhi Qiu
    Citation: BMC Cancer 2024 24:175
    Content type: Research Published on:

  25. High levels of physical activity are associated with reduced risk of the blood cancer multiple myeloma (MM). MM is preceded by the asymptomatic stages of monoclonal gammopathy of undetermined significance (MGU...

    Authors: A Emery, S Moore, J Crowe, J Murray, O Peacock, D Thompson, F Betts, S Rapps, L Ross, D Rothschild-Rodriguez, A Arana Echarri, R Davies, R Lewis, DX Augustine, A Whiteway, Z Afzal…
    Citation: BMC Cancer 2024 24:174
    Content type: Research Published on:

  26. Copy-number alterations (CNAs) are a hallmark of cancer and can regulate cancer cell states via altered gene expression values. Herein, we have developed a copy-number impact (CNI) analysis method that quantif...

    Authors: Sanaz Jamalzadeh, Jun Dai, Kari Lavikka, Yilin Li, Jing Jiang, Kaisa Huhtinen, Anni Virtanen, Jaana Oikkonen, Sakari Hietanen, Johanna Hynninen, Anna Vähärautio, Antti Häkkinen and Sampsa Hautaniemi
    Citation: BMC Cancer 2024 24:173
    Content type: Research Published on:

  27. Epithelioid sarcoma is a rare soft tissue sarcoma characterized by SMARCB1/INI1 deficiency. Much attention has been paid to the selective EZH2 inhibitor tazemetostat, where other systemic treatments are genera...

    Authors: Lu Xie, Xin Sun, Jie Xu, Xin Liang, Kuisheng Liu, Kunkun Sun, Rongli Yang, Xiaodong Tang and Wei Guo
    Citation: BMC Cancer 2024 24:172
    Content type: Research Published on:

  28. Radiotherapy delivery regimens can vary between a single fraction (SF) and multiple fractions (MF) given daily for up to several weeks depending on the location of the cancer or metastases. With limited eviden...

    Authors: Robert Olson, Hadassah Abraham, Curtis Leclerc, Alexander Benny, Sarah Baker, Quinn Matthews, Nick Chng, Alanah Bergman, Benjamin Mou, Emma M. Dunne, Devin Schellenberg, Will Jiang, Elisa Chan, Siavash Atrchian, Shilo Lefresne, Hannah Carolan…
    Citation: BMC Cancer 2024 24:171
    Content type: Study Protocol Published on:

  29. The prognosis of SCLC is poor and difficult to predict. The aim of this study was to explore whether a model based on radiomics and clinical features could predict the prognosis of patients with limited-stage ...

    Authors: Jiehan Wu, Yuntao Zhou, Chang Xu, Chengwen Yang, Bingxin Liu, Lujun Zhao, Jiawei Song, Wei Wang, Yining Yang and Ningbo Liu
    Citation: BMC Cancer 2024 24:170
    Content type: Research Published on:

  30. This study aimed to compare the efficacy of focused ultrasound (FUS) and the loop electrosurgical excision procedure (LEEP) for the treatment of cervical high-grade squamous intraepithelial lesions (HSILs) amo...

    Authors: Linlin Xiao, Xu Dong, Jiangchuan Sun, Xuerui Zhang, Qing Feng and Shufang Chang
    Citation: BMC Cancer 2024 24:169
    Content type: Research Published on:

  31. Oxaliplatin-induced peripheral neuropathy (OIPN) in general and painful OIPN in particular is a debilitating late effect that severely affects cancer survivors’ quality of life and causes premature cessation o...

    Authors: Nina Lykkegaard Gehr, Páll Karlsson, Signe Timm, Signe Christensen, Christian Andreas Hvid, Jana Peric, Torben Frøstrup Hansen, Lotte Lauritzen, Nanna Brix Finnerup and Lise Ventzel
    Citation: BMC Cancer 2024 24:168
    Content type: Study Protocol Published on:

  32. Breast carcinoma (BC) ranks as a predominant malignancy and constitutes the second principal cause of mortality among women globally. Epirubicin stands as the drug of choice for BC therapeutics. Nevertheless, ...

    Authors: Yunwei Zhang, Yunping Guan, Xinyu Zheng and Chenyang Li
    Citation: BMC Cancer 2024 24:167
    Content type: Research Published on:

  33. Osteosarcoma (OS) is a highly malignant tumor, and its dysregulated lipid metabolism is associated with tumorigenesis and unfavorable prognosis. Interestingly, long noncoding RNAs (lncRNAs) have emerged as piv...

    Authors: Feng Cai, Luhua Liu, Yuan Bo, Wenjing Yan, Xuchang Tao, Yuanxiang Peng, Zhiping Zhang, Qi Liao and Yangyan Yi
    Citation: BMC Cancer 2024 24:166
    Content type: Research Published on:

  34. To improve the prognosis of patients with metastatic colorectal cancer (mCRC), investigating predictive biomarkers of their prognosis and chemotherapeutic responsiveness is necessary. This study aimed to analy...

    Authors: Kei Furuya, Masao Nakajima, Ryouichi Tsunedomi, Yuki Nakagami, Ming Xu, Hiroto Matsui, Yukio Tokumitsu, Yoshitaro Shindo, Yusaku Watanabe, Shinobu Tomochika, Noriko Maeda, Michihisa Iida, Nobuaki Suzuki, Shigeru Takeda, Shoichi Hazama, Tatsuya Ioka…
    Citation: BMC Cancer 2024 24:165
    Content type: Research Published on:

  35. For high-risk stageIImismatch repair deficient (dMMR) colon cancers, the benefit of adjuvant chemotherapy remains debatable. The principal aim of this study was to evaluate the prognostic value of high-risk fa...

    Authors: Leen Liao, Jinghua Tang, Zhigang Hong, Wu Jiang, Yuan Li, Lingheng Kong, Kai Han, Zhenlin Hou, Chenzhi Zhang, Chi Zhou, Linjie Zhang, Qiaoqi Sui, Binyi Xiao, Weijian Mei, Jiehai Yu, Wanjun Yang…
    Citation: BMC Cancer 2024 24:164
    Content type: Research Published on:

  36. Despite advancements in managing metastatic clear cell renal carcinoma (mccRCC) through antiangiogenic tyrosine kinase inhibitors and immunotherapy, there remains a demand for novel treatments for patients exp...

    Authors: David Kryza, Armelle Vinceneux, Anne-Sophie Bidaux, Gwenaelle Garin, Delphine Tatu, Claire Cropet, Jean-Noël Badel, David Perol and Anne-Laure Giraudet
    Citation: BMC Cancer 2024 24:163
    Content type: Study Protocol Published on:

  37. Colorectal cancer (CRC) is a common malignancy worldwide. MicroRNAs (miRNAs) are important epigenetic alterations that notably impact various physiological and pathological processes by acting as negative regu...

    Authors: Bayan Mehrjoei, Lida Haghnazari, Homayoon Bashiri and Nayebali Rezvani
    Citation: BMC Cancer 2024 24:162
    Content type: Research Published on:

  38. In 2020, the highest incidence and mortality from cervical cancer (CC) were detected in low and middle-income countries. CC remains a health problem for women living in them. In Mexico, CC ranks second in canc...

    Authors: Lucely Cetina-Pérez, Julissa Luvián-Morales, Merari Delgadillo-González, Denisse Castro-Eguiluz, Tatiana Galicia-Carmona, Kely Rely, Rita Vaca González, Gabriela Lugo-Martínez, Nadia García-Barrientos and Antonio Nateras
    Citation: BMC Cancer 2024 24:161
    Content type: Research Published on:

  39. This study aims to explore the priorities and counselling needs of patients with muscle-invasive bladder cancer faced with a decision between radical cystectomy and trimodality therapy.

    Authors: Flor Verghote, Charles Van Praet, Camille Berquin, Nicolaas Lumen, Karel Decaestecker, Ben Vanneste, Elke Rammant and Valérie Fonteyne
    Citation: BMC Cancer 2024 24:160
    Content type: Research Published on:

  40. This study was designed to evaluate the safety and feasibility of laparoscopic radical cystectomy (LRC) for male octogenarian patients with muscle-invasive bladder cancer (MIBC). Briefly, a total of 57 male oc...

    Authors: Dong-liang Pan, Lu-fang Zhang, Xiao-jian Li, Ke-ping Zhang, Peng-fei Gao, Bing Yang and Ning-chen Li
    Citation: BMC Cancer 2024 24:159
    Content type: Research Published on:

  41. Guidelines recommend cardiovascular risk assessment and counseling for cancer survivors. For effective implementation, it is critical to understand survivor cardiovascular health (CVH) profiles and perspective...

    Authors: Kathryn E. Weaver, Emily V. Dressler, Sydney Smith, Chandylen L. Nightingale, Heidi D. Klepin, Simon Craddock Lee, Brian J. Wells, W. Gregory Hundley, Joseph A. DeMari, Sarah N. Price and Randi E. Foraker
    Citation: BMC Cancer 2024 24:158
    Content type: Research Published on:

  43. Lactate dehydrogenase (LDHs) is an enzyme involved in anaerobic glycolysis, including LDHA, LDHB, LDHC and LDHD. Given the regulatory role in the biological progression of certain tumors, we analyzed the role ...

    Authors: Shengnan Wang, Xingwei Wu, Xiaoming Wu, Jin Cheng, Qianyi Chen and Zhilin Qi
    Citation: BMC Cancer 2024 24:156
    Content type: Research Published on:

  44. Breast cancer remains a significant health challenge worldwide, necessitating the identification of reliable biomarkers for early detection, accurate prognosis, and targeted therapy.

    Authors: Ali Golestan, Ahmad Tahmasebi, Nafiseh Maghsoodi, Seyed Nooreddin Faraji, Cambyz Irajie and Amin Ramezani
    Citation: BMC Cancer 2024 24:155
    Content type: Research Published on:

  45. The increasing cancer burden calls for reliably assessed changes in the hospitalizations for tumors over time and space in China. This study evaluated trends in hospitalization rate, in-hospital mortality, len...

    Authors: Xinqiang Zhang, Yuanyuan Li, Guifang Zhang, Changsheng Ma, Bo Liu and Yong Yin
    Citation: BMC Cancer 2024 24:154
    Content type: Research Published on:

  46. Neoadjuvant immune checkpoint inhibitors(ICIs) combined with chemotherapy can improve non-small cell lung cancer(NSCLC) patients' pathological responses and show promising improvements in survival. Chronic obs...

    Authors: Weigang Dong, Yan Yin, Shengnan Yang, Bin Liu, Xi Chen, Lina Wang, Yue Su, Yan Jiang, Dongsheng Shi, Daqiang Sun and Jianwen Qin
    Citation: BMC Cancer 2024 24:153
    Content type: Research Published on:

  47. While immunotherapy combined with chemotherapy (Chemo-IO) is generally recognized for providing superior outcomes compared to monotherapy (mono-IO), it is associated with a higher incidence of treatment-relate...

    Authors: Sangwon Shin, Jimin Moon, Chiyoon Oum, Seulki Kim, Soo Ick Cho, Yoojoo Lim, Chan-Young Ock and Seunghwan Shin
    Citation: BMC Cancer 2024 24:152
    Content type: Research Published on:

  48. The existing staging system cannot meet the needs of accurate survival prediction. Accurate survival prediction for locally advanced cervical cancer (LACC) patients who have undergone concurrent radiochemother...

    Authors: Huiling Liu, Yongbin Cui, Cheng Chang, Zichun Zhou, Yalin Zhang, Changsheng Ma, Yong Yin and Ruozheng Wang
    Citation: BMC Cancer 2024 24:150
    Content type: Research Published on:

  49. Physician-brief advice has been utilized in high-income countries to promote smoking cessation among cancer patients. Empirical evidence on its effectiveness among cancer patients in low and middle-income coun...

    Authors: Olayinka Stephen Ilesanmi, Babalola Faseru, Aanuoluwapo Adeyimika Afolabi, Olukemi Odukoya, Olalekan Ayo-Yusuf, Folahanmi Akinsolu, Akindele Olupelumi Adebiyi and William K. Evans
    Citation: BMC Cancer 2024 24:149
    Content type: Research Published on:

  50. Pediatric low-grade glioma (pLGG) is essentially a single pathway disease, with most tumors driven by genomic alterations affecting the mitogen-activated protein kinase/ERK (MAPK) pathway, predominantly KIAA1549:...

    Authors: Cornelis M. van Tilburg, Lindsay B. Kilburn, Sébastien Perreault, Rene Schmidt, Amedeo A. Azizi, Ofelia Cruz-Martínez, Michal Zápotocký, Katrin Scheinemann, Antoinette Y. N. Schouten-van Meeteren, Astrid Sehested, Enrico Opocher, Pablo Hernáiz Driever, Shivaram Avula, David S. Ziegler, David Capper, Arend Koch…
    Citation: BMC Cancer 2024 24:147
    Content type: Study Protocol Published on:

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